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    spock3 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3 [ Danio rerio (zebrafish) ]

    Gene ID: 562002, updated on 9-Dec-2024

    Summary

    Official Symbol
    spock3provided by ZNC
    Official Full Name
    SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090311-24
    See related
    Ensembl:ENSDARG00000070266 AllianceGenome:ZFIN:ZDB-GENE-090311-24
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7139568; si:dkey-285b22.1
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be located in extracellular region. Is expressed in cardiovascular system; hypural; nervous system; and neural tube. Orthologous to human SPOCK3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See spock3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (20635190..20706298)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (19942253..20013361)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 Neighboring gene UDP glycosyltransferase 8 Neighboring gene tolloid-like 1 Neighboring gene carboxypeptidase E

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    testican-3
    Names
    sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
    testican 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001327987.1NP_001314916.1  testican-3 isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a),
      Source sequence(s)
      CR381587, EB939186, EH433753, EH447295, EH458122, EH468737
      UniProtKB/TrEMBL
      A0A0R4IMY5, A0A8M1P8M2, A0A8M3BEW5
      Related
      ENSDARP00000135664.2, ENSDART00000166479.2
      Conserved Domains (4) summary
      smart00280
      Location:106149
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:275339
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:161277
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:160265
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region
    2. NM_001327988.1NP_001314917.1  testican-3 isoform b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      CR381587, EB939186, EH433753, EH447295, EH458122, EH468737
      UniProtKB/TrEMBL
      A0A8M1P451, A0A8M3BEW5, F1RAX3
      Related
      ENSDARP00000123781.1, ENSDART00000148518.3
      Conserved Domains (4) summary
      smart00280
      Location:103146
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:272336
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:158274
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:157262
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      20635190..20706298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017355108.2XP_017210597.1  testican-3 isoform X1

      UniProtKB/TrEMBL
      A0A8M3BEW5, A0A8M6YZL5
      Related
      ENSDARP00000093744.4, ENSDART00000102969.5

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395210.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      581507..652614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)