fkbp1b FKBP prolyl isomerase 1B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fkbp1bprovided by ZNC
Official Full Name: FKBP prolyl isomerase 1Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1785
See related: Ensembl:ENSDARG00000052625 AllianceGenome:ZFIN:ZDB-GENE-040426-1785
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:73381; si:dkeyp-115a10.1
Summary: Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be active in sarcoplasmic reticulum membrane. Is expressed in basal plate midbrain region; brain; cranial ganglion; and myotome. Human ortholog(s) of this gene implicated in Graves' disease. Orthologous to human FKBP1B (FKBP prolyl isomerase 1B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (44464345..44496234, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (44566339..44598218, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in sarcoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase FKBP1B

Names: FK506 binding protein 1b

NP_957106.1

EC 5.2.1.8

XP_068071496.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200812.2 → NP_957106.1 peptidyl-prolyl cis-trans isomerase FKBP1B

See identical proteins and their annotated locations for NP_957106.1

Status: VALIDATED

Source sequence(s)

BX664630, CR545466

UniProtKB/TrEMBL

A0A8M1PBT7, Q6PBJ1

Related

ENSDARP00000021881.6, ENSDART00000012229.8

Conserved Domains (1) summary

COG0545
Location:2 → 106

FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]