id2b inhibitor of DNA binding 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: id2bprovided by ZNC
Official Full Name: inhibitor of DNA binding 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-15
See related: Ensembl:ENSDARG00000029544 AllianceGenome:ZFIN:ZDB-GENE-030131-15
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: id2l; zgc:73382; hm:zeh0152
Summary: Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and neuron differentiation. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including cardiovascular system; liver; nervous system; notochord; and pronephric duct. Orthologous to human ID2 (inhibitor of DNA binding 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (29784930..29787225, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (29882041..29884394, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Notch signaling via Hey1 and Id2b regulates Muller glia's regenerative response to retinal injury.
Title: Notch signaling via Hey1 and Id2b regulates Müller glia's regenerative response to retinal injury.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DNA-binding protein inhibitor ID-2b

Names: inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, b; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199541.1 → NP_955835.1 DNA-binding protein inhibitor ID-2b

See identical proteins and their annotated locations for NP_955835.1

Status: PROVISIONAL

Source sequence(s)

BC059690

UniProtKB/TrEMBL

A0A8M2B7R3, Q6PBJ0

Related

ENSDARP00000048758.3, ENSDART00000048759.4

Conserved Domains (1) summary

cd00083
Location:36 → 77

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

29784930..29787225 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005160630.3 → XP_005160687.1 DNA-binding protein inhibitor ID-2b isoform X1

See identical proteins and their annotated locations for XP_005160687.1

UniProtKB/TrEMBL

A0A8M2B7R3, Q6PBJ0

Related

ENSDARP00000108958.2, ENSDART00000125348.3

Conserved Domains (1) summary

cd00083
Location:36 → 77

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...