kcnh2a potassium voltage-gated channel, subfamily H (eag-related), member 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kcnh2aprovided by ZNC
Official Full Name: potassium voltage-gated channel, subfamily H (eag-related), member 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070912-699
See related: Ensembl:ENSDARG00000029881 AllianceGenome:ZFIN:ZDB-GENE-070912-699
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: kcnh2; kcnh2l; si:dkeyp-99c4.6
Summary: Predicted to enable voltage-gated potassium channel activity. Acts upstream of or within fin morphogenesis and negative regulation of calcineurin-mediated signaling. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Is expressed in several structures, including digestive system; fin; gill; heart; and immune system. Human ortholog(s) of this gene implicated in long QT syndrome; long QT syndrome 2; and short QT syndrome. Orthologous to human KCNH2 (potassium voltage-gated channel subfamily H member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (24080590..24170737)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (24425399..24512605)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

longfin causes cis-ectopic expression of the kcnh2a ether-a-go-go K+ channel to autonomously prolong fin outgrowth.
Title: longfin causes cis-ectopic expression of the kcnh2a ether-a-go-go K+ channel to autonomously prolong fin outgrowth.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fin morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within fin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of calcineurin-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily H member 2a

Names: potassium voltage-gated channel subfamily H member 2-like; potassium voltage-gated channel, subfamily H (eag-related), member 2 like; zerg-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042722.2 → NP_001036187.2 potassium voltage-gated channel subfamily H member 2a

Status: VALIDATED

Source sequence(s)

BX000358, CR788285

UniProtKB/TrEMBL

A0A8M9QG33, Q108P2

Related

ENSDARP00000009558.7, ENSDART00000024058.10

Conserved Domains (3) summary

cd00038
Location:744 → 855

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:407 → 670

Ion_trans; Ion transport protein

pfam13426
Location:29 → 130

PAS_9; PAS domain