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    ptprc protein tyrosine phosphatase receptor type C [ Danio rerio (zebrafish) ]

    Gene ID: 559154, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ptprcprovided by ZNC
    Official Full Name
    protein tyrosine phosphatase receptor type Cprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050208-585
    See related
    AllianceGenome:ZFIN:ZDB-GENE-050208-585
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:eu845; si:dkeyp-47c5.1
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in membrane. Is expressed in common myeloid progenitor; epicardium; and hematopoietic system. Human ortholog(s) of this gene implicated in multiple sclerosis; primary immunodeficiency disease; and severe combined immunodeficiency. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See ptprc in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (22977257..23068394, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (22962477..23056068, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488931 Neighboring gene microRNA mir-181b-3 Neighboring gene microRNA 181a-1 Neighboring gene uncharacterized protein DDB_G0290587-like Neighboring gene uncharacterized LOC137488933 Neighboring gene uncharacterized LOC137488934 Neighboring gene uncharacterized LOC137489016 Neighboring gene NIMA-related kinase 7 Neighboring gene LIM homeobox 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Definitive hematopoiesis initiates through a committed erythromyeloid progenitor in the zebrafish embryo. Bertrand JY, et al. Development, 2007 Dec. PMID 17959717, Free PMC Article
    2. Purification of zebrafish erythrocytes as a means of identifying a novel regulator of haematopoiesis. Kulkeaw K, et al. Br J Haematol, 2018 Feb. PMID 29265183, Free PMC Article
    3. Haematopoietic stem cells derive directly from aortic endothelium during development. Bertrand JY, et al. Nature, 2010 Mar 4. PMID 20154733, Free PMC Article
    4. CD41+ cmyb+ precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis. Bertrand JY, et al. Development, 2008 May. PMID 18417622, Free PMC Article
    5. The gata1/pu.1 lineage fate paradigm varies between blood populations and is modulated by tif1γ. Monteiro R, et al. EMBO J, 2011 Mar 16. PMID 21336259, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase C
    Names
    CD45 antigen
    XP_068072741.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      22977257..23068394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068216640.1 → XP_068072741.1  receptor-type tyrosine-protein phosphatase C

      UniProtKB/TrEMBL
      A0A8M9PK73
    Nucleotide Protein Strain
    Heading Accession and Version

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