pycr3 pyrroline-5-carboxylate reductase 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pycr3provided by ZNC
Official Full Name: pyrroline-5-carboxylate reductase 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-041014-244
See related: Ensembl:ENSDARG00000015236 AllianceGenome:ZFIN:ZDB-GENE-041014-244
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pycrl; si:dkey-235d18.3
Summary: Predicted to enable pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process. Predicted to act upstream of or within proline biosynthetic process. Predicted to be located in cytosol. Orthologous to human PYCR3 (pyrroline-5-carboxylate reductase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 20

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (52529051..52541661)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (52723477..52735896)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables pyrroline-5-carboxylate reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyrroline-5-carboxylate reductase activity	IEA Inferred from Electronic Annotation more info
enables pyrroline-5-carboxylate reductase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-proline biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-proline biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-proline biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proline biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: pyrroline-5-carboxylate reductase 3

Names: P5C reductase 3; P5CR 3; pyrroline-5-carboxylate reductase-like protein

NP_001038403.1

EC 1.5.1.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044938.1 → NP_001038403.1 pyrroline-5-carboxylate reductase 3

See identical proteins and their annotated locations for NP_001038403.1

Status: PROVISIONAL

Source sequence(s)

AL929003

UniProtKB/Swiss-Prot

Q05AI4, Q5SPD7

Related

ENSDARP00000011713.7, ENSDART00000002787.10

Conserved Domains (3) summary

PLN02688
Location:20 → 283

PLN02688; pyrroline-5-carboxylate reductase

pfam03807
Location:22 → 114

F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

pfam14748
Location:176 → 280

P5CR_dimer; Pyrroline-5-carboxylate reductase dimerization