arl6ip1 ARL6 interacting reticulophagy regulator 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: arl6ip1provided by ZNC
Official Full Name: ARL6 interacting reticulophagy regulator 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1087
See related: Ensembl:ENSDARG00000054578 AllianceGenome:ZFIN:ZDB-GENE-040426-1087
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: arl6ip; zgc:56593; zgc:77873
Summary: Acts upstream of or within neural crest cell migration and retina morphogenesis in camera-type eye. Predicted to be part of Sec61 translocon complex. Predicted to be active in membrane. Is expressed in several structures, including blastodisc; central nervous system; hypochord; optic cup; and retina. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 61. Orthologous to human ARL6IP1 (ADP ribosylation factor like GTPase 6 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (31104891..31115947, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (30974049..30985105, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arl6ip1 not only affects signals controlling eye development but also plays an important role in the proliferation of retinal progenitor cells.
Title: Arl6ip1 plays a role in proliferation during zebrafish retinogenesis.
arl6ip1 is required for neural crest migration and sublineage specification.
Title: Zebrafish arl6ip1 is required for neural crest development during embryogenesis.
Results suggest that Arl6ip may play important roles in zebrafish ocular, heart, and fin-bud development.
Title: The embryonic expression patterns and the knockdown phenotypes of zebrafish ADP-ribosylation factor-like 6 interacting protein gene.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cotranslational protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neural crest cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Sec61 translocon complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ADP-ribosylation factor-like protein 6-interacting protein 1

Names: ADP-ribosylation factor-like 6 interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.