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    arhgap12b Rho GTPase activating protein 12b [ Danio rerio (zebrafish) ]

    Gene ID: 393848, updated on 9-Dec-2024

    Summary

    Official Symbol
    arhgap12bprovided by ZNC
    Official Full Name
    Rho GTPase activating protein 12bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1727
    See related
    Ensembl:ENSDARG00000026482 AllianceGenome:ZFIN:ZDB-GENE-040426-1727
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    arhgap12; zgc:73239
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be active in cytoplasm and plasma membrane. Is expressed in retina and somite. Orthologous to human ARHGAP12 (Rho GTPase activating protein 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See arhgap12b in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (26622052..26725798)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (26530654..26634598)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110440143 Neighboring gene potassium channel tetramerization domain containing 2 Neighboring gene hexosaminidase d Neighboring gene zinc finger E-box binding homeobox 1b Neighboring gene uncharacterized LOC137496819 Neighboring gene zinc finger protein 438

    Genomic regions, transcripts, and products

    General protein information

    Preferred Names
    rho GTPase-activating protein 12b
    Names
    Rho GTPase activating protein 12

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200874.1NP_957168.1  rho GTPase-activating protein 12b

      See identical proteins and their annotated locations for NP_957168.1

      Status: PROVISIONAL

      Source sequence(s)
      BC063321
      UniProtKB/TrEMBL
      Q6P4P5
      Related
      ENSDARP00000046958.3, ENSDART00000046959.5
      Conserved Domains (6) summary
      cd12070
      Location:1776
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:624810
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:435546
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:449544
      PH; PH domain
      pfam00397
      Location:271297
      WW; WW domain
      pfam16618
      Location:73267
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      26622052..26725798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068224534.1XP_068080635.1  rho GTPase-activating protein 12b isoform X2

    2. XM_021480040.2XP_021335715.1  rho GTPase-activating protein 12b isoform X1

      UniProtKB/TrEMBL
      A0A8M9QME4
      Conserved Domains (5) summary
      cd12070
      Location:1776
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:689875
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:459611
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:271297
      WW; WW domain
      pfam16618
      Location:73267
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
    3. XM_021480041.2XP_021335716.1  rho GTPase-activating protein 12b isoform X3

      UniProtKB/TrEMBL
      A0A8M9QIL2
      Conserved Domains (5) summary
      cd12070
      Location:1776
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:688874
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:459611
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:271297
      WW; WW domain
      pfam16618
      Location:73267
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
    4. XM_009306595.4XP_009304870.1  rho GTPase-activating protein 12b isoform X5

      UniProtKB/TrEMBL
      A0A0R4IKK1, A0A8M3BE39
      Related
      ENSDARP00000134177.2, ENSDART00000158440.2
      Conserved Domains (6) summary
      cd12070
      Location:1776
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:648834
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:459570
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:473568
      PH; PH domain
      pfam00397
      Location:271297
      WW; WW domain
      pfam16618
      Location:73267
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12
    5. XM_021480042.2XP_021335717.1  rho GTPase-activating protein 12b isoform X4

      UniProtKB/TrEMBL
      A0A8M9PW53
      Conserved Domains (5) summary
      cd12070
      Location:1776
      SH3_ARHGAP12; Src Homology 3 domain of Rho GTPase-activating protein 12
      cd04403
      Location:665851
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:435587
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:271297
      WW; WW domain
      pfam16618
      Location:73267
      SH3-WW_linker; Linker region between SH3 and WW domains on ARHGAP12

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394846.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      75425..182061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)