pitpnb phosphatidylinositol transfer protein, beta [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pitpnbprovided by ZNC
Official Full Name: phosphatidylinositol transfer protein, betaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-895
See related: Ensembl:ENSDARG00000036005 AllianceGenome:ZFIN:ZDB-GENE-040426-895
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:56092
Summary: Enables phosphatidylcholine transporter activity and phosphatidylinositol transfer activity. Acts upstream of or within intermembrane lipid transfer; phospholipid transport; and photoreceptor cell outer segment organization. Located in trans-Golgi network. Is expressed in eye; retinal cone cell; retinal outer plexiform layer; and retinal photoreceptor layer. Orthologous to human PITPNB (phosphatidylinositol transfer protein beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (4046376..4087018)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (4046072..4086714)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pitpnb expression is particularly robust in double cone cells of the zebrafish retina
Title: Zebrafish class 1 phosphatidylinositol transfer proteins: PITPbeta and double cone cell outer segment integrity in retina.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables phosphatidylcholine binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylcholine transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylcholine transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phospholipid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within photoreceptor cell outer segment organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphatidylinositol transfer protein beta isoform

Names: phosphotidylinositol transfer protein, beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001328435.1 → NP_001315364.1 phosphatidylinositol transfer protein beta isoform isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region that results in a frameshift and an early stop codon compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

CABZ01068908, CABZ01068909, CABZ01068911

UniProtKB/TrEMBL

A0A8M1PA15, E7EZR3

Related

ENSDARP00000111558.3, ENSDART00000123086.3

Conserved Domains (1) summary

cd08888
Location:3 → 259

SRPBCC_PITPNA-B_like; Lipid-binding SRPBCC domain of mammalian PITPNA, -B, and related proteins (Class I PITPs)
NM_200920.2 → NP_957214.2 phosphatidylinositol transfer protein beta isoform isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).

Source sequence(s)

CABZ01068908, CABZ01068909, CABZ01068911

UniProtKB/TrEMBL

A0A8M1PBY8, F1QRW4

Related

ENSDARP00000052267.4, ENSDART00000052268.6