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    plk4 polo-like kinase 4 (Drosophila) [ Danio rerio (zebrafish) ]

    Gene ID: 368390, updated on 9-Dec-2024

    Summary

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    Official Symbol
    plk4provided by ZNC
    Official Full Name
    polo-like kinase 4 (Drosophila)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030619-14
    See related
    Ensembl:ENSDARG00000004576 AllianceGenome:ZFIN:ZDB-GENE-030619-14
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    stk18; wu:fi33g07
    Summary
    Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within centriole assembly; cilium assembly; and developmental growth. Predicted to be located in deuterosome; microtubule organizing center; and nucleolus. Predicted to be active in nucleus. Is expressed in brain; eye; nervous system; and pronephros. Used to study ciliopathy. Human ortholog(s) of this gene implicated in microcephaly and chorioretinopathy 2. Orthologous to human PLK4 (polo like kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See plk4 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (43410751..43428397, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (43420213..43437859, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene EMAP like 5 Neighboring gene uncharacterized LOC137488135 Neighboring gene inositol-tetrakisphosphate 1-kinase b Neighboring gene heat shock protein 4 like Neighboring gene charged multivesicular body protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain. Sredni ST, et al. Pediatr Blood Cancer, 2017 Nov. PMID 28398638
    2. Developmental role of plk4 in Xenopus laevis and Danio rerio: implications for Seckel Syndrome. Rapchak CE, et al. Biochem Cell Biol, 2015 Aug. PMID 26150138
    3. Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy. Martin CA, et al. Nat Genet, 2014 Dec. PMID 25344692, Free PMC Article
    4. PLK1- and PLK4-Mediated Asymmetric Mitotic Centrosome Size and Positioning in the Early Zebrafish Embryo. Rathbun LI, et al. Curr Biol, 2020 Nov 16. PMID 32916112, Free PMC Article
    5. Excess centrosomes disrupt vascular lumenization and endothelial cell adherens junctions. Buglak DB, et al. Angiogenesis, 2020 Nov. PMID 32699963, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PLK1- and PLK4-Mediated Asymmetric Mitotic Centrosome Size and Positioning in the Early Zebrafish Embryo.
      Title: PLK1- and PLK4-Mediated Asymmetric Mitotic Centrosome Size and Positioning in the Early Zebrafish Embryo.
    2. results provide the first steps in defining a new role for plk4 in organogenesis and implies a role in planar cell polarity, segmentation, and in recently described PLK4 mutations in human
      Title: Developmental role of plk4 in Xenopus laevis and Danio rerio: implications for Seckel Syndrome.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within centriole assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centriole replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of centriole replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in deuterosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PLK4
    Names
    PLK-4
    serine/threonine kinase 18
    serine/threonine-protein kinase Sak
    NP_001112364.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001118892.1 → NP_001112364.1  serine/threonine-protein kinase PLK4

      Status: PROVISIONAL

      Source sequence(s)
      CR405694
      UniProtKB/Swiss-Prot
      Q7ZVS3
      UniProtKB/TrEMBL
      A0A8M1NG63, F1RB74
      Related
      ENSDARP00000043865.6, ENSDART00000043866.7
      Conserved Domains (5) summary
      smart00220
      Location:12 → 265
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13114
      Location:566 → 676
      POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13115
      Location:677 → 786
      POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd13116
      Location:856 → 935
      POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)
      cd14186
      Location:10 → 265
      STKc_PLK4; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      43410751..43428397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZVS3.2 GenPept UniProtKB/Swiss-Prot:Q7ZVS3

    Gene LinkOut

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