atp5md ATP synthase membrane subunit k [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: atp5mdprovided by ZNC
Official Full Name: ATP synthase membrane subunit kprovided by ZNC
Primary source: ZFIN:ZDB-GENE-110914-234
See related: Ensembl:ENSDARG00000096003 AllianceGenome:ZFIN:ZDB-GENE-110914-234
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: USMG5; si:dkeyp-80c12.10
Summary: Predicted to be located in membrane and mitochondrion. Predicted to be part of proton-transporting ATP synthase complex. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 6. Orthologous to human ATP5MK (ATP synthase membrane subunit k). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (49432148..49434891, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (48787728..48790471, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

When endogenous z-usmg5 in zebrafish was disrupted using morpholino (MO) oligonucleotides, the pericardial sac and atrial areas were larger and ventricular fractional shortening was reduced compared to in the control MO group. The expression levels of natriuretic peptides were upregulated in the z-usmg5 MO group compared to in controls. Genes in the calcium signalling pathway were downregulated in the z-usmg5 MO group.
Title: Heat Failure Phenotypes Induced by Knockdown of DAPIT in Zebrafish: A New Insight into Mechanism of Dilated Cardiomyopathy.

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General gene information

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Gene Ontology Provided by ZFIN

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of proton-transporting ATP synthase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ATP synthase membrane subunit K, mitochondrial

Names: ATP synthase membrane subunit DAPIT; diabetes- associated protein in insulin-sensitive tissue (DAPIT); up-regulated during skeletal muscle growth protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001200033.1 → NP_001186962.1 ATP synthase membrane subunit K, mitochondrial

Status: VALIDATED

Source sequence(s)

BC150375, DR729439, EH496800

UniProtKB/TrEMBL

A0A8M1NV68, H0WES8

Related

ENSDARP00000125277.1, ENSDART00000150789.3

Conserved Domains (1) summary

pfam14960
Location:1 → 51

ATP_synth_reg; ATP synthase regulation