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    rgs9a regulator of G protein signaling 9a [ Danio rerio (zebrafish) ]

    Gene ID: 767636, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rgs9aprovided by ZNC
    Official Full Name
    regulator of G protein signaling 9aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060929-92
    See related
    Ensembl:ENSDARG00000037925 AllianceGenome:ZFIN:ZDB-GENE-060929-92
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rgs9; wipi1; zgc:152760
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in G protein-coupled dopamine receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway; intracellular signal transduction; and regulation of signal transduction. Predicted to be active in cytoplasm; neuron projection; and plasma membrane. Is expressed in eye. Human ortholog(s) of this gene implicated in bradyopsia 1. Orthologous to human RGS9 (regulator of G protein signaling 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rgs9a in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (36366546..36401994)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (36236948..36259806)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 16 member 6b Neighboring gene guanine nucleotide binding protein (G protein), alpha 13b Neighboring gene si:ch1073-443f11.2 Neighboring gene component of oligomeric golgi complex 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Circadian regulation of vertebrate cone photoreceptor function. Zang J, et al. Elife, 2021 Sep 22. PMID 34550876, Free PMC Article
    2. Functional Differentiation of BMP7 Genes in Zebrafish: bmp7a for Dorsal-Ventral Pattern and bmp7b for Melanin Synthesis and Eye Development. Dong XR, et al. Front Cell Dev Biol, 2022. PMID 35372349, Free PMC Article
    3. Lxr regulates lipid metabolic and visual perception pathways during zebrafish development. Pinto CL, et al. Mol Cell Endocrinol, 2016 Jan 5. PMID 26427652, Free PMC Article
    4. Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia. Zhang P, et al. Cell Rep, 2014 Mar 27. PMID 24613356
    5. RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio. Saddala MS, et al. BMC Genomics, 2020 Feb 7. PMID 32033529, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC152760

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled dopamine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    regulator of G-protein signaling 9a
    Names
    WD repeat domain, phosphoinositide interacting 1
    regulator of G-protein signaling 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001327800.1 → NP_001314729.1  regulator of G-protein signaling 9a

      Status: VALIDATED

      Source sequence(s)
      CABZ01019467, CU855789, LO018534
      UniProtKB/TrEMBL
      A0A2R8QUQ1, A0A8M1P8B2
      Related
      ENSDARP00000157261.1, ENSDART00000181140.1
      Conserved Domains (3) summary
      smart00224
      Location:223 → 283
      GGL; G protein gamma subunit-like motifs
      cd04450
      Location:25 → 112
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      cl02565
      Location:295 → 415
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      36366546..36401994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068217649.1 → XP_068073750.1  regulator of G-protein signaling 9a isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001076577.2: Suppressed sequence

      Description
      NM_001076577.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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