U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    map2k6 mitogen-activated protein kinase kinase 6 [ Danio rerio (zebrafish) ]

    Gene ID: 65239, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    map2k6provided by ZNC
    Official Full Name
    mitogen-activated protein kinase kinase 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010202-3
    See related
    Ensembl:ENSDARG00000099184 AllianceGenome:ZFIN:ZDB-GENE-010202-3
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    MKK3; zMKK3; map2k3
    Summary
    Predicted to enable MAP kinase kinase activity. Involved in positive regulation of p38MAPK cascade. Predicted to be located in several cellular components, including cytoplasm; cytoskeleton; and nucleus. Human ortholog(s) of this gene implicated in Pick's disease; cervical cancer; ovarian carcinoma; progressive supranuclear palsy; and restrictive cardiomyopathy. Orthologous to human MAP2K6 (mitogen-activated protein kinase kinase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See map2k6 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (36109071..36159881)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (36414816..36465626)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 142 Neighboring gene BTB (POZ) domain containing 17a Neighboring gene potassium inwardly rectifying channel subfamily J member 2a Neighboring gene potassium inwardly rectifying channel subfamily J member 16a

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mitogen-activated protein kinase kinase 6 is involved in the immune response to bacterial di-/tripeptide challenge in grass carp Ctenopharyngodon idella. Qu F, et al. Fish Shellfish Immunol, 2019 Jan. PMID 30393177
    2. Characteristics of the New Insulin-Resistant Zebrafish Model. Nam YH, et al. Pharmaceuticals (Basel), 2021 Jul 4. PMID 34358068, Free PMC Article
    3. Asymmetric p38 activation in zebrafish: its possible role in symmetric and synchronous cleavage. Fujii R, et al. J Cell Biol, 2000 Sep 18. PMID 10995439, Free PMC Article
    4. Activation of MEK2 is sufficient to induce skin papilloma formation in transgenic zebrafish. Chou CM, et al. J Biomed Sci, 2015 Nov 17. PMID 26572230, Free PMC Article
    5. Proteomic Profiling of Zebrafish Challenged by Spring Viremia of Carp Virus Provides Insight into Skin Antiviral Response. Liu R, et al. Zebrafish, 2020 Apr. PMID 32176570

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of p38MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    dual specificity mitogen-activated protein kinase kinase 6
    NP_001299799.1
    XP_068080748.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001312870.1 → NP_001299799.1  dual specificity mitogen-activated protein kinase kinase 6

      Status: VALIDATED

      Source sequence(s)
      AL954682, CU467923, DR720420, EH448857
      UniProtKB/Swiss-Prot
      Q6IQW6, Q9DGE0
      Related
      ENSDARP00000141647.1, ENSDART00000171268.2
      Conserved Domains (2) summary
      cd06617
      Location:78 → 360
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
      smart00220
      Location:81 → 341
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      36109071..36159881
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068224647.1 → XP_068080748.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_131724.1: Suppressed sequence

      Description
      NM_131724.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DGE0.2 GenPept UniProtKB/Swiss-Prot:Q9DGE0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.