ptgis prostaglandin I2 (prostacyclin) synthase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptgisprovided by ZNC
Official Full Name: prostaglandin I2 (prostacyclin) synthaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070116-1
See related: Ensembl:ENSDARG00000060094 AllianceGenome:ZFIN:ZDB-GENE-070116-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: PGIS; ptgisl
Summary: Enables heme binding activity and prostaglandin-I synthase activity. Involved in prostaglandin biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); colorectal adenoma; limb ischemia; and primary pulmonary hypertension. Orthologous to human PTGIS (prostaglandin I2 synthase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (46568283..46589726, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (46566401..46587844, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

crystal structures of ligand-free, inhibitor (minoxidil)-bound and substrate analog U51605-bound PGIS
Title: Structures of prostacyclin synthase and its complexes with substrate analog and inhibitor reveal a ligand-specific heme conformation change.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heme binding	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables hydroperoxy icosatetraenoate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables prostaglandin-I synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin-I synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin-I synthase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within prostaglandin biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within prostaglandin metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prostacyclin synthase

Names: hydroperoxy icosatetraenoate dehydratase; prostaglandin I2 (prostacyclin) synthase like; prostaglandin I2 synthase

NP_001104630.1

EC 4.2.1.152

EC 5.3.99.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.