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    pias4b protein inhibitor of activated STAT, 4b [ Danio rerio (zebrafish) ]

    Gene ID: 393314, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pias4bprovided by ZNC
    Official Full Name
    protein inhibitor of activated STAT, 4bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1298
    See related
    Ensembl:ENSDARG00000042215 AllianceGenome:ZFIN:ZDB-GENE-040426-1298
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    pias4l; zgc:63923; wu:fi26h11
    Summary
    Predicted to enable SUMO ligase activity and transcription coregulator activity. Predicted to be involved in protein sumoylation and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Is expressed in several structures, including gill; heart; integument; liver; and pleuroperitoneal region. Orthologous to human PIAS4 (protein inhibitor of activated STAT 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pias4b in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (57447105..57476462, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (57312951..57342308, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene transcription factor 3a Neighboring gene uncharacterized LOC137488345 Neighboring gene mitogen-activated protein kinase kinase 2b Neighboring gene one cut homeobox 3b Neighboring gene leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of a PIAS4 homologue from zebrafish: insights into its conserved negative regulatory mechanism in the TRIF, MAVS, and IFN signaling pathways during vertebrate evolution. Xiong R, et al. J Immunol, 2012 Mar 15. PMID 22345667
    2. Early depletion of primordial germ cells in zebrafish promotes testis formation. Tzung KW, et al. Stem Cell Reports, 2015 Jan 13. PMID 25434820, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63923

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 SUMO-protein ligase PIAS4b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242942.1 → NP_001229871.1  E3 SUMO-protein ligase PIAS4b isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream start codon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      CABZ01044182, EH491696, EH543530, EH570193
      UniProtKB/TrEMBL
      A0A2R8Q3K8, A0A8M1P1Y4
      Related
      ENSDARP00000145407.1, ENSDART00000192201.1
      Conserved Domains (3) summary
      smart00513
      Location:2 → 36
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:273 → 320
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:91 → 220
      PINIT; PINIT domain

    2. NM_200343.2 → NP_956637.2  E3 SUMO-protein ligase PIAS4b isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      EH491696, EH543530, EH570193
      UniProtKB/TrEMBL
      A0A8N1TYF8, F8W4B9
      Related
      ENSDARP00000124244.1, ENSDART00000150034.3
      Conserved Domains (3) summary
      smart00513
      Location:42 → 76
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam02891
      Location:313 → 360
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:131 → 260
      PINIT; PINIT domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      57447105..57476462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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