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    POR C-CAP/cofactor C-like domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830151, updated on 18-Sep-2024

    Summary

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    Official Symbol
    POR
    Official Full Name
    C-CAP/cofactor C-like domain-containing protein
    Primary source
    TAIR:AT4G39920
    Locus tag
    AT4G39920
    See related
    Araport:AT4G39920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    PORCINO; T5J17.90; T5J17_90; TFC C; TUBULIN-FOLDING COFACTOR C
    Summary
    Microtubule-folding cofactor, produces assembly-competent alpha-/beta-tubulin heterodimers.
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    Genomic context

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    See POR in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    1
    Sequence:
    Chromosome: 4; NC_003075.7 (18515693..18517302)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-specific protease 3 Neighboring gene low-molecular-weight cysteine-rich 45 Neighboring gene AT hook motif DNA-binding family protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of the tubulin-folding cofactor C in Arabidopsis thaliana. Kirik V, et al. Curr Biol, 2002 Sep 3. PMID 12225668
    2. FC2 stabilizes POR and suppresses ALA formation in the tetrapyrrole biosynthesis pathway. Fan T, et al. New Phytol, 2023 Jul. PMID 37161708
    3. Mutations in the pilz group genes disrupt the microtubule cytoskeleton and uncouple cell cycle progression from cell division in Arabidopsis embryo and endosperm. Mayer U, et al. Eur J Cell Biol, 1999 Feb. PMID 10099932
    4. The Arabidopsis PILZ group genes encode tubulin-folding cofactor orthologs required for cell division but not cell growth. Steinborn K, et al. Genes Dev, 2002 Apr 15. PMID 11959844, Free PMC Article
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FC2 stabilizes POR and suppresses ALA formation in the tetrapyrrole biosynthesis pathway.
      Title: FC2 stabilizes POR and suppresses ALA formation in the tetrapyrrole biosynthesis pathway.
    Submit: New GeneRIF Correction

    General gene information

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    NM_120155.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytokinesis by cell plate formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-chaperonin tubulin folding pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tubulin complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within tubulin complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    C-CAP/cofactor C-like domain-containing protein
    NP_195702.1
    • PORCINO (POR); FUNCTIONS IN: binding; INVOLVED IN: tubulin complex assembly, cytokinesis; LOCATED IN: cytoplasm; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: CARP motif (InterPro:IPR006599), C-CAP/cofactor C-like domain (InterPro:IPR017901), Tubulin binding cofactor C (InterPro:IPR012945); Has 497 Blast hits to 493 proteins in 165 species: Archae - 0; Bacteria - 11; Metazoa - 222; Fungi - 88; Plants - 54; Viruses - 0; Other Eukaryotes - 122 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      18515693..18517302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120155.4 → NP_195702.1  C-CAP/cofactor C-like domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195702.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L5R4, Q9SMR2
      UniProtKB/TrEMBL
      A0A178UWP1, A0A5S9Y2E6
      Conserved Domains (2) summary
      pfam07986
      Location:199 → 316
      TBCC; Tubulin binding cofactor C
      pfam16752
      Location:17 → 139
      TBCC_N; Tubulin-specific chaperone C N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SMR2.1

    Gene LinkOut

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