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    MBD5 methyl-CPG-binding domain protein 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823811, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MBD5
    Official Full Name
    methyl-CPG-binding domain protein 5
    Primary source
    TAIR:AT3G46580
    Locus tag
    AT3G46580
    See related
    Araport:AT3G46580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMBD5; MBD05; MDB05; METHYL-CPG-BINDING DOMAIN PROTEIN 05; methyl-CPG-binding domain protein 5
    Summary
    Protein containing a putative methyl-CpG-binding domain.Has sequence similarity to human MBD proteins.
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    Genomic context

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    See MBD5 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    3
    Sequence:
    Chromosome: 3; NC_003074.8 (17148232..17149597)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene NAC (No apical meristem) domain transcriptional regulator superfamily protein Neighboring gene Glycosyl hydrolase superfamily protein Neighboring gene tRNA-Gly Neighboring gene TRF-like 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interaction between methyl CpG-binding protein and ran GTPase during cell division in tobacco cultured cells. Yano A, et al. Ann Bot, 2006 Dec. PMID 17008347, Free PMC Article
    2. Arabidopsis MBD proteins show different binding specificities and nuclear localization. Scebba F, et al. Plant Mol Biol, 2003 Nov. PMID 15010609
    3. The three methyl-CpG-binding domains of AtMBD7 control its subnuclear localization and mobility. Zemach A, et al. J Biol Chem, 2008 Mar 28. PMID 18211904, Free PMC Article
    4. DDM1 binds Arabidopsis methyl-CpG binding domain proteins and affects their subnuclear localization. Zemach A, et al. Plant Cell, 2005 May. PMID 15805479, Free PMC Article
    5. Methylated DNA-binding proteins from Arabidopsis. Ito M, et al. Plant Physiol, 2003 Dec. PMID 14605234, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study showed that AtMBD5 becomes localized to the vicinity of chromosomes with the aid of AtRAN3 during cell division.
      Title: Interaction between methyl CpG-binding protein and ran GTPase during cell division in tobacco cultured cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_114525.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables methyl-CpG binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyl-CpG binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in perinucleolar chromocenter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methyl-CPG-binding domain protein 5
    NP_190242.1
    • methyl-CPG-binding domain protein 5 (MBD5); FUNCTIONS IN: methyl-CpG binding, DNA binding; INVOLVED IN: biological_process unknown; LOCATED IN: perinucleolar chromocenter; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Methyl-CpG DNA binding (InterPro:IPR001739); BEST Arabidopsis thaliana protein match is: methyl-CPG-binding domain 6 (TAIR:AT5G59380.1); Has 120 Blast hits to 118 proteins in 32 species: Archae - 0; Bacteria - 0; Metazoa - 64; Fungi - 4; Plants - 49; Viruses - 0; Other Eukaryotes - 3 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      17148232..17149597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114525.3 → NP_190242.1  methyl-CPG-binding domain protein 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190242.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LCG6, Q9SNC0
      UniProtKB/TrEMBL
      A0A178VD62, A0A5S9XIC8, A0A654FEP7
      Conserved Domains (1) summary
      cd01396
      Location:29 → 110
      MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SNC0.1

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