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    HMT2 homocysteine methyltransferase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825500, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HMT2
    Official Full Name
    homocysteine methyltransferase 2
    Primary source
    TAIR:AT3G63250
    Locus tag
    AT3G63250
    See related
    Araport:AT3G63250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATHMT-2; HMT-2; homocysteine methyltransferase 2; HOMOCYSTEINE METHYLTRANSFERASE-2
    Summary
    Encodes a homocysteine methyltransferase (HMT). Among the three HMT coding genes in the genome, HMT2 is responsible for a significant proportion of HMT activity in the flower stalks and silique hulls. However, HMT2 does not significantly contribute to the total HMT activity in seeds.
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    Genomic context

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    See HMT2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    8
    Sequence:
    Chromosome: 3; NC_003074.8 (23369781..23372823, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene DNAse I-like superfamily protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Protein kinase superfamily protein Neighboring gene nuclease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reduced activity of Arabidopsis thaliana HMT2, a methionine biosynthetic enzyme, increases seed methionine content. Lee M, et al. Plant J, 2008 Apr. PMID 18208517
    2. Characterization and functional expression of cDNAs encoding methionine-sensitive and -insensitive homocysteine S-methyltransferases from Arabidopsis. Ranocha P, et al. J Biol Chem, 2000 May 26. PMID 10747987
    3. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The effects of mutatios of HMT2 on methionine biosynthesis in A. thaliana are reported.
      Title: Reduced activity of Arabidopsis thaliana HMT2, a methionine biosynthetic enzyme, increases seed methionine content.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001340195.1
    NM_116190.5
    NM_202753.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables S-adenosylmethionine-homocysteine S-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables S-methylmethionine-homocysteine S-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within S-methylmethionine cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within methionine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    homocysteine methyltransferase 2
    NP_001319825.1
    • homocysteine methyltransferase 2 (HMT2); CONTAINS InterPro DOMAIN/s: Homocysteine S-methyltransferase (InterPro:IPR003726); BEST Arabidopsis thaliana protein match is: homocysteine S-methyltransferase 3 (TAIR:AT3G22740.1); Has 6768 Blast hits to 6760 proteins in 1892 species: Archae - 4; Bacteria - 4264; Metazoa - 340; Fungi - 135; Plants - 163; Viruses - 0; Other Eukaryotes - 1862 (source: NCBI BLink).
    NP_974482.1
    • homocysteine methyltransferase 2 (HMT2); FUNCTIONS IN: homocysteine S-methyltransferase activity; INVOLVED IN: methionine biosynthetic process, S-methylmethionine cycle; LOCATED IN: endomembrane system; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Homocysteine S-methyltransferase (InterPro:IPR003726); BEST Arabidopsis thaliana protein match is: homocysteine S-methyltransferase 3 (TAIR:AT3G22740.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      23369781..23372823 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001340195.1 → NP_001319825.1  homocysteine methyltransferase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WTD0, Q9M1W4, Q9SDL6
      UniProtKB/TrEMBL
      A0A178VA42, A0A5S9XNL2

    2. NM_116190.5 → NP_191884.1  homocysteine methyltransferase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191884.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WTD0, Q9M1W4, Q9SDL6
      UniProtKB/TrEMBL
      A0A178VA42, A0A5S9XNL2
      Conserved Domains (1) summary
      PLN02489
      Location:1 → 331
      PLN02489; homocysteine S-methyltransferase

    3. NM_202753.2 → NP_974482.1  homocysteine methyltransferase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974482.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VA42, A0A5S9XNL2, F4J0X9
      Conserved Domains (1) summary
      PLN02489
      Location:8 → 291
      PLN02489; homocysteine S-methyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M1W4.1

    Gene LinkOut

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