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    VAR3 zinc finger (Ran-binding) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831647, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VAR3
    Official Full Name
    zinc finger (Ran-binding) family protein
    Primary source
    TAIR:AT5G17790
    Locus tag
    AT5G17790
    See related
    Araport:AT5G17790
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MVA3.15; MVA3_15; VARIEGATED 3
    Summary
    Encodes a 85.9 kDa protein containing novel repeats and zinc fingers described as protein interaction domains. VAR3 is a part of a protein complex required for normal chloroplast and palisade cell development. Mutants display a variegated phenotype due to somatic areas lacking or containing developmentally retarded chloroplasts and greatly reduced numbers of palisade cells.
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    Genomic context

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    See VAR3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (5869696..5872782, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene NADH:cytochrome B5 reductase 1 Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene myb domain protein 56

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The RanBP2 zinc finger domains of chloroplast RNA editing factor OZ1 are required for protein-protein interactions and conversion of C to U. Gipson AB, et al. Plant J, 2022 Jan. PMID 34743362
    2. Arabidopsis VARIEGATED 3 encodes a chloroplast-targeted, zinc-finger protein required for chloroplast and palisade cell development. Naested H, et al. J Cell Sci, 2004 Sep 15. PMID 15340011
    3. An Organelle RNA Recognition Motif Protein Is Required for Photosystem II Subunit psbF Transcript Editing. Hackett JB, et al. Plant Physiol, 2017 Apr. PMID 28213559, Free PMC Article
    4. A zinc finger motif-containing protein is essential for chloroplast RNA editing. Sun T, et al. PLoS Genet, 2015 Mar. PMID 25768119, Free PMC Article
    5. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_121785.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast mRNA modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chloroplast organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger (Ran-binding) family protein
    NP_197281.1
    • VARIEGATED 3 (VAR3); FUNCTIONS IN: binding, zinc ion binding; INVOLVED IN: chloroplast organization; LOCATED IN: chloroplast, chloroplast stroma; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RanBP2-type (InterPro:IPR001876); BEST Arabidopsis thaliana protein match is: zinc finger (Ran-binding) family protein (TAIR:AT1G55040.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5869696..5872782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121785.3 → NP_197281.1  zinc finger (Ran-binding) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197281.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q64M74, Q8S9K3, Q9FN73
      UniProtKB/TrEMBL
      A0A654G245
      Conserved Domains (2) summary
      sd00029
      Location:280 → 299
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:278 → 304
      zf-RanBP; Zn-finger in Ran binding protein and others
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8S9K3.2

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