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    FAR1 fatty acid reductase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832311, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FAR1
    Official Full Name
    fatty acid reductase 1
    Primary source
    TAIR:AT5G22500
    Locus tag
    AT5G22500
    See related
    Araport:AT5G22500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    fatty acid reductase 1; MQJ16.4; MQJ16_4
    Summary
    Encodes a member of the eight-member gene family encoding alcohol-forming fatty acyl-CoA reductases (FARs) identified in Arabidopsis thaliana. Three of the FARs, FAR1 (At5g22500), FAR4 (At3g44540) and FAR5 (At3g44550), are shown to generate the fatty alcohols found in root, seed coat, and wound-induced leaf tissue.
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    Genomic context

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    See FAR1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Sequence:
    Chromosome: 5; NC_003076.8 (7470328..7474133)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene O-acyltransferase (WSD1-like) family protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene alkaline/neutral invertase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis FHY3 and FAR1 Regulate the Balance between Growth and Defense Responses under Shade Conditions. Liu Y, et al. Plant Cell, 2019 Sep. PMID 31311834, Free PMC Article
    2. Suberin-associated fatty alcohols in Arabidopsis: distributions in roots and contributions to seed coat barrier properties. Vishwanath SJ, et al. Plant Physiol, 2013 Nov. PMID 24019425, Free PMC Article
    3. Three Arabidopsis fatty acyl-coenzyme A reductases, FAR1, FAR4, and FAR5, generate primary fatty alcohols associated with suberin deposition. Domergue F, et al. Plant Physiol, 2010 Aug. PMID 20571114, Free PMC Article
    4. Functional expression of five Arabidopsis fatty acyl-CoA reductase genes in Escherichia coli. Doan TT, et al. J Plant Physiol, 2009 May 15. PMID 19062129
    5. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis FHY3 and FAR1 Regulate the Balance between Growth and Defense Responses under Shade Conditions.
      Title: Arabidopsis FHY3 and FAR1 Regulate the Balance between Growth and Defense Responses under Shade Conditions.
    2. Data indicate that down-regulation of Arabidopsis FATTY ACYL REDUCTASE1 (FAR1), FAR4, and FAR5, which collectively produce the fatty alcohols found in suberin, reduced their levels by 70% to 80%.
      Title: Suberin-associated fatty alcohols in Arabidopsis: distributions in roots and contributions to seed coat barrier properties.
    3. FAR1, FAR4, and FAR5 generate the fatty alcohols found in root, seed coat, and wound-induced leaf tissue.
      Title: Three Arabidopsis fatty acyl-coenzyme A reductases, FAR1, FAR4, and FAR5, generate primary fatty alcohols associated with suberin deposition.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001343737.1
    NM_122155.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables alcohol-forming long-chain fatty acyl-CoA reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain-fatty-acyl-CoA reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to salt stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within suberin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    fatty acid reductase 1
    NP_197642.1
    • fatty acid reductase 1 (FAR1); FUNCTIONS IN: oxidoreductase activity, acting on the CH-CH group of donors, fatty-acyl-CoA reductase (alcohol-forming) activity, long-chain-fatty-acyl-CoA reductase activity; INVOLVED IN: response to salt stress, microsporogenesis, response to wounding, suberin biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Male sterility (InterPro:IPR004262), NAD(P)-binding domain (InterPro:IPR016040), Male sterility, NAD-binding (InterPro:IPR013120); BEST Arabidopsis thaliana protein match is: fatty acid reductase 4 (TAIR:AT3G44540.1); Has 2592 Blast hits to 2555 proteins in 497 species: Archae - 6; Bacteria - 759; Metazoa - 1002; Fungi - 307; Plants - 285; Viruses - 0; Other Eukaryotes - 233 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      7470328..7474133
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122155.4 → NP_197642.1  fatty acid reductase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197642.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39152
      UniProtKB/TrEMBL
      A0A5S9Y754
      Conserved Domains (1) summary
      PLN02996
      Location:1 → 490
      PLN02996; fatty acyl-CoA reductase

    2. NM_001343737.1 → NP_001331256.1  fatty acid reductase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BDD4, A0A5S9Y754
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39152.1

    Gene LinkOut

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