SGR4 Vesicle transport v-SNARE family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: SGR4
Official Full Name: Vesicle transport v-SNARE family protein
Primary source: TAIR:AT5G39510
Locus tag: AT5G39510
See related: Araport:AT5G39510
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATVTI11; ATVTI1A; IMPAIRED TONOPLAST TRAFFIC 3; ITT3; MUL8.190; MUL8_190; SHOOT GRAVITROPSIM 4; VESICLE TRANSPORT V-SNARE 11; VTI11; VTI1A; ZIG; ZIG1
Summary: Encodes a member of SNARE gene family. Homologous with yeast VTI1 and is involved in vesicle transport. Mutant alleles such as sgr4/zig are defective in the shoots response to gravity resulting in a zigzag growth pattern of the stem. Involved in protein trafficking to lytic vacuoles. Can conditionally substitute VTI12 in protein storage vacuole trafficking when plants are devoid of VTI12.
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Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

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The prevacuolar compartment SNARE protein VTI11 is essential for Turnip mosaic virus infection and replication.
Title: Turnip Mosaic Virus Uses the SNARE Protein VTI11 in an Unconventional Route for Replication Vesicle Trafficking.
The vacuoles in itt3/vti11 are independent organelles. Results provided supporting evidence for a critical role of PtdIns(3)P in vacuole fusion in roots and guard cells. [ITT3]
Title: Multiple vacuoles in impaired tonoplast trafficking3 mutants are independent organelles.
Homotypic vacuole fusion requires VTI11 and is regulated by phosphoinositides.
Title: Homotypic vacuole fusion requires VTI11 and is regulated by phosphoinositides.
The frequency of bulbs is affected in the three sgr mutants sgr2, sgr3 and sgr4/zig.
Title: The occurrence of 'bulbs', a complex configuration of the vacuolar membrane, is affected by mutations of vacuolar SNARE and phospholipase in Arabidopsis.
Functional deficiency of the retromer large subunit suppresses the loss-of-function mutant of Qb-SNARE VTI11, zig-1.
Title: Loss-of-function mutations of retromer large subunit genes suppress the phenotype of an Arabidopsis zig mutant that lacks Qb-SNARE VTI11.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_123313.5

Function	Evidence Code	Pubs
enables SNAP receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi to vacuole transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within gravitropism	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular transport of virus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect lytic vacuole organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein targeting to vacuole	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle fusion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	TAS Traceable Author Statement more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plastid	HDA more info	PubMed
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	TAS Traceable Author Statement more info	PubMed
located_in trans-Golgi network transport vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in vacuolar membrane	HDA more info	PubMed
located_in vacuole	HDA more info	PubMed

NP_198767.1

SHOOT GRAVITROPSIM 4 (SGR4); FUNCTIONS IN: receptor activity; INVOLVED IN: gravitropism, Golgi to vacuole transport, protein targeting to vacuole; LOCATED IN: in 7 components; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Vesicle transport v-SNARE, N-terminal (InterPro:IPR007705); BEST Arabidopsis thaliana protein match is: vesicle transport V-snare 13 (TAIR:AT3G29100.1); Has 744 Blast hits to 742 proteins in 201 species: Archae - 0; Bacteria - 0; Metazoa - 276; Fungi - 144; Plants - 174; Viruses - 0; Other Eukaryotes - 150 (source: NCBI BLink).

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