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    Clathrin adaptor complexes medium subunit family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834706, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Clathrin adaptor complexes medium subunit family protein
    Primary source
    TAIR:AT5G46630
    Locus tag
    AT5G46630
    See related
    Araport:AT5G46630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    adaptor protein-2 mu-adaptin; AP2M
    Summary
    clathrin adaptor complexes medium subunit family protein, contains Pfam profile: PF00928 adaptor complexes medium subunit family; similar to micro-adaptins of clathrin coated vesicle adaptor complexes
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    13
    Sequence:
    Chromosome: 5; NC_003076.8 (18920334..18923551)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene aluminum activated malate transporter family protein Neighboring gene uncharacterized protein Neighboring gene AT hook motif DNA-binding family protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The μ Subunit of Arabidopsis Adaptor Protein-2 Is Involved in Effector-Triggered Immunity Mediated by Membrane-Localized Resistance Proteins. Hatsugai N, et al. Mol Plant Microbe Interact, 2016 May. PMID 26828402
    2. The endocytosis of cellulose synthase in Arabidopsis is dependent on μ2, a clathrin-mediated endocytosis adaptin. Bashline L, et al. Plant Physiol, 2013 Sep. PMID 23843604, Free PMC Article
    3. Phosphorylation of ADAPTOR PROTEIN-2 μ-adaptin by ADAPTOR-ASSOCIATED KINASE1 regulates the tropic growth of Arabidopsis roots. Siao W, et al. Plant Cell, 2023 Sep 1. PMID 37440281, Free PMC Article
    4. Trafficking of the human transferrin receptor in plant cells: effects of tyrphostin A23 and brefeldin A. Ortiz-Zapater E, et al. Plant J, 2006 Dec. PMID 17059402
    5. Adaptor protein complex 2-mediated endocytosis is crucial for male reproductive organ development in Arabidopsis. Kim SY, et al. Plant Cell, 2013 Aug. PMID 23975898, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation of ADAPTOR PROTEIN-2 mu-adaptin by ADAPTOR-ASSOCIATED KINASE1 regulates the tropic growth of Arabidopsis roots.
      Title: Phosphorylation of ADAPTOR PROTEIN-2 μ-adaptin by ADAPTOR-ASSOCIATED KINASE1 regulates the tropic growth of Arabidopsis roots.
    2. These results suggest that the mu subunit of adaptor protein 2 (AP-2) is involved in effector-triggered immunity mediated by plasma membrane-localized R proteins.[AP2M]
      Title: The μ Subunit of Arabidopsis Adaptor Protein-2 Is Involved in Effector-Triggered Immunity Mediated by Membrane-Localized Resistance Proteins.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_124033.4
    NM_203166.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    Clathrin adaptor complexes medium subunit family protein
    NP_199475.1
    • Clathrin adaptor complexes medium subunit family protein; INVOLVED IN: intracellular protein transport, transport, vesicle-mediated transport; LOCATED IN: clathrin vesicle coat, plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Clathrin adaptor, mu subunit, conserved site (InterPro:IPR018240), Clathrin adaptor, mu subunit, C-terminal (InterPro:IPR008968), Clathrin adaptor, mu subunit (InterPro:IPR001392), Clathrin coat associated protein AP-50 (InterPro:IPR015629), Longin-like (InterPro:IPR011012); BEST Arabidopsis thaliana protein match is: Clathrin adaptor complexes medium subunit family protein (TAIR:AT1G60780.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
    NP_974895.1
    • Clathrin adaptor complexes medium subunit family protein; INVOLVED IN: intracellular protein transport, transport, vesicle-mediated transport; LOCATED IN: clathrin vesicle coat, plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Clathrin adaptor, mu subunit, conserved site (InterPro:IPR018240), Clathrin adaptor, mu subunit, C-terminal (InterPro:IPR008968), Clathrin adaptor, mu subunit (InterPro:IPR001392), Clathrin coat associated protein AP-50 (InterPro:IPR015629), Longin-like (InterPro:IPR011012); BEST Arabidopsis thaliana protein match is: Clathrin adaptor complexes medium subunit family protein (TAIR:AT1G60780.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      18920334..18923551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124033.4 → NP_199475.1  Clathrin adaptor complexes medium subunit family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199475.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DI54, O23140
      UniProtKB/TrEMBL
      A0A178UQZ5, A0A5S9YC44
      Conserved Domains (2) summary
      cd09251
      Location:175 → 437
      AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2
      cd14836
      Location:6 → 144
      AP2_Mu_N; AP-2 complex subunit mu N-terminal domain

    2. NM_203166.2 → NP_974895.1  Clathrin adaptor complexes medium subunit family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974895.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4KHJ7
      Conserved Domains (1) summary
      cd09251
      Location:175 → 413
      AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O23140.1

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