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    Dhx9 DExH-box helicase 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304859, updated on 27-Nov-2024

    Summary

    Official Symbol
    Dhx9provided by RGD
    Official Full Name
    DExH-box helicase 9provided by RGD
    Primary source
    RGD:1308548
    See related
    EnsemblRapid:ENSRNOG00000002735 AllianceGenome:RGD:1308548
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including helicase activity; nucleic acid binding activity; and ribonucleoprotein complex binding activity. Predicted to be involved in several processes, including DNA geometric change; regulation of defense response; and regulation of gene expression. Predicted to act upstream of or within cellular response to heat and circadian rhythm. Predicted to be located in several cellular components, including cytoskeleton; nuclear lumen; and ribonucleoprotein granule. Predicted to be part of CRD-mediated mRNA stability complex; RISC complex; and RISC-loading complex. Predicted to be active in nucleolus. Orthologous to human DHX9 (DExH-box helicase 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 219.5), Thymus (RPKM 203.5) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dhx9 in Genome Data Viewer
    Location:
    13q21
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (68152813..68189580, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (65602322..65639098, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (70885503..70922278, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene laminin subunit gamma 1 Neighboring gene ornithine decarboxylase-like Neighboring gene SHC binding and spindle associated 1 like Neighboring gene N-acetylneuraminate pyruvate lyase Neighboring gene S100 calcium binding protein A11, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3'-5' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3'-5' DNA/RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3'-5' RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA replication origin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RISC complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA stem-loop binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables importin-alpha family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleoside triphosphate diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables regulatory region RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables siRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded 3'-5' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables triplex DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in CRD-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA-templated transcription termination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA-templated viral transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G-quadruplex DNA unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RISC complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA secondary structure unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in cellular response to exogenous dsRNA ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in miRNA-mediated post-transcriptional gene silencing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of RNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-alpha production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-18 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of viral transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyroptotic inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of mRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of CRD-mediated mRNA stability complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RISC complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RISC-loading complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perichromatin fibrils ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ATP-dependent RNA helicase A
    Names
    DEAH (Asp-Glu-Ala-His) box helicase 9
    DEAH (Asp-Glu-Ala-His) box polypeptide 9
    DEAH-box helicase 9
    NP_001382485.1
    XP_006250058.1
    XP_008767855.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395556.1NP_001382485.1  ATP-dependent RNA helicase A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6ABZ7, A6ICV0, D4A9D6
      Related
      ENSRNOP00000090956.1, ENSRNOT00000116976.2
      Conserved Domains (4) summary
      COG1643
      Location:3371055
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      cd17972
      Location:333566
      DEXHc_DHX9; DEXH-box helicase domain of DEAH-box helicase 9
      cd19854
      Location:371
      DSRM_DHX9_rpt1; first double-stranded RNA binding motif of DEAH box protein 9 (DHX9) and similar proteins
      cd19855
      Location:181255
      DSRM_DHX9_rpt2; second double-stranded RNA binding motif of DEAH box protein 9 (DHX9) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      68152813..68189580 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249996.5XP_006250058.1  ATP-dependent RNA helicase A isoform X1

      UniProtKB/TrEMBL
      A6ICV0, D4A9D6
      Related
      ENSRNOP00000061368.2, ENSRNOT00000064860.3
      Conserved Domains (6) summary
      smart00358
      Location:569
      DSRM; Double-stranded RNA binding motif
      smart00487
      Location:384571
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:840921
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:407548
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00271
      Location:637770
      Helicase_C; Helicase conserved C-terminal domain
      pfam07717
      Location:9611075
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    2. XM_008769633.3XP_008767855.1  ATP-dependent RNA helicase A isoform X2

      UniProtKB/TrEMBL
      A6ICV0, D4A9D6
      Conserved Domains (5) summary
      smart00487
      Location:168355
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:624705
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:191332
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00271
      Location:421554
      Helicase_C; Helicase conserved C-terminal domain
      pfam07717
      Location:745859
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107184.1: Suppressed sequence

      Description
      NM_001107184.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.