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    GCH GTP cyclohydrolase II [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836551, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GCH
    Official Full Name
    GTP cyclohydrolase II
    Primary source
    TAIR:AT5G64300
    Locus tag
    AT5G64300
    See related
    Araport:AT5G64300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA GTP CYCLOHYDROLASE II; Arabidopsis thaliana riboflavin A1; ATGCH; ATRIBA1; GTP cyclohydrolase II; GTP CYCLOHYDROLASE II; RED FLUORESCENT IN DARKNESS 1; RFD1; RIBA1; riboflavin A1
    Summary
    encodes GTP cyclohydrolase II that can functionally complement E. coli mutant deficient in this gene. It also has 3,4-dihydroxy-2-butanone-4-phosphate synthase activity which makes it a bifunctional enzyme involved in the formation of the pyrimidine and of the carbohydrate from GTP and ribulose-5-phosphate, respectively
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    Genomic context

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    See GCH in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (25718008..25721166)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene splicing factor Neighboring gene dicarboxylate transporter 2.2 Neighboring gene dicarboxylate transport 2.1 Neighboring gene arabinogalactan protein 1 Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deficiency in riboflavin biosynthesis affects tetrapyrrole biosynthesis in etiolated Arabidopsis tissue. Hedtke B, et al. Plant Mol Biol, 2012 Jan. PMID 22081402
    2. Biosynthesis of riboflavin in plants. The ribA gene of Arabidopsis thaliana specifies a bifunctional GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase. Herz S, et al. Phytochemistry, 2000 Apr. PMID 10783978
    3. Isolation of cDNAs encoding GTP cyclohydrolase II from Arabidopsis thaliana. Kobayashi M, et al. Gene, 1995 Jul 28. PMID 7642114
    4. Arabidopsis RIBA proteins: two out of three isoforms have lost their bifunctional activity in riboflavin biosynthesis. Hiltunen HM, et al. Int J Mol Sci, 2012 Oct 31. PMID 23203051, Free PMC Article
    5. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that RIBA1 (At5g64300) catalyses the initial reaction of the metabolic pathway of riboflavin biosynthesis.
      Title: Deficiency in riboflavin biosynthesis affects tetrapyrrole biosynthesis in etiolated Arabidopsis tissue.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_125826.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3,4-dihydroxy-2-butanone-4-phosphate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3,4-dihydroxy-2-butanone-4-phosphate synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables GTP cyclohydrolase II activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP cyclohydrolase II activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in riboflavin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within riboflavin biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in riboflavin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 

    General protein information

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    Preferred Names
    GTP cyclohydrolase II
    NP_201235.4
    • GTP cyclohydrolase II (GCH); FUNCTIONS IN: 3,4-dihydroxy-2-butanone-4-phosphate synthase activity, GTP cyclohydrolase II activity; INVOLVED IN: riboflavin biosynthetic process; LOCATED IN: chloroplast, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: GTP cyclohydrolase II (InterPro:IPR000926), DHBP synthase RibB (InterPro:IPR000422), DHBP synthase RibB-like alpha/beta domain (InterPro:IPR017945); BEST Arabidopsis thaliana protein match is: riboflavin biosynthesis protein, putative (TAIR:AT2G22450.1); Has 11690 Blast hits to 11688 proteins in 2324 species: Archae - 209; Bacteria - 6956; Metazoa - 1; Fungi - 397; Plants - 132; Viruses - 0; Other Eukaryotes - 3995 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25718008..25721166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125826.5 → NP_201235.4  GTP cyclohydrolase II [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201235.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P47924, Q9SBA8
      UniProtKB/TrEMBL
      A0A178UCT4, A0A5S9YI36, A0A654GE08
      Conserved Domains (1) summary
      PLN02831
      Location:93 → 542
      PLN02831; Bifunctional GTP cyclohydrolase II/ 3,4-dihydroxy-2-butanone-4-phosphate synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47924.2

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