Alas1 5'-aminolevulinate synthase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Alas1provided by RGD
Official Full Name: 5'-aminolevulinate synthase 1provided by RGD
Primary source: RGD:68392
See related: EnsemblRapid:ENSRNOG00000056596 AllianceGenome:RGD:68392
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ALAS; ALA-S; ALAS-H; ALAS-N
Summary: Enables 5-aminolevulinate synthase activity. Involved in several processes, including cellular response to insulin stimulus; response to herbicide; and response to nickel cation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in mitochondrial matrix. Biomarker of porphyria and pulmonary hypertension. Orthologous to human ALAS1 (5'-aminolevulinate synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 1059.5), Adrenal (RPKM 879.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (115755238..115768642, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (106876514..106889917, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (114927704..114941038, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

REV-ERBalpha has a role in circadian oscillation in the expressions of Alas1, Ppargc1a, and Il6 genes in rat granulosa cells
Title: Integration of the nuclear receptor REV-ERBα linked with circadian oscillators in the expressions of Alas1, Ppargc1a, and Il6 genes in rat granulosa cells.
Pulmonary HO-1 was presumably induced by proinflammatory cytokine(s) in MCT-treated rats, resulting in derepression of heme-repressible ALAS1 expression. HO-1 induction plays significant inflammatory role.(Delta-aminolevulinate synthase)
Title: Increased pulmonary heme oxygenase-1 and delta-aminolevulinate synthase expression in monocrotaline-induced pulmonary hypertension.
Ethanol treatment induces ALAS1 gene expression.
Title: Tissue-specific expression of ALA synthase-1 and heme oxygenase-1 and their expression in livers of rats chronically exposed to ethanol.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 5-aminolevulinate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5-aminolevulinate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables 5-aminolevulinate synthase activity	IEA Inferred from Electronic Annotation more info
enables 5-aminolevulinate synthase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in erythrocyte development	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme A biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in heme A biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heme B biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in heme B biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heme O biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in heme O biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heme biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hemoglobin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protoporphyrinogen IX biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in response to bile acid	IEA Inferred from Electronic Annotation more info
involved_in response to bile acid	ISO Inferred from Sequence Orthology more info
involved_in response to bile acid	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cobalt ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to gonadotropin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to herbicide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nickel cation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to platinum ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 5-aminolevulinate synthase, non-specific, mitochondrial

Names: 5-aminolevulinate synthase 1; 5-aminolevulinate synthase, nonspecific, mitochondrial; 5-aminolevulinic acid synthase 1; aminolevulinate, delta-, synthase 1; aminolevulinic acid synthase 1; delta-ALA synthase 1; delta-ALA synthetase; delta-aminolevulinate synthase 1

NP_077810.2

EC 2.3.1.37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024484.3 → NP_077810.2 5-aminolevulinate synthase, non-specific, mitochondrial precursor

See identical proteins and their annotated locations for NP_077810.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P13195, Q6P782

UniProtKB/TrEMBL

A0A0G2K962, A6I2Q2

Related

ENSRNOP00000074873.3, ENSRNOT00000086232.3

Conserved Domains (2) summary

pfam09029
Location:2 → 140

Preseq_ALAS; 5-aminolevulinate synthase presequence

cl18945
Location:199 → 604

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...