Hyal2 hyaluronidase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hyal2provided by RGD
Official Full Name: hyaluronidase 2provided by RGD
Primary source: RGD:620321
See related: EnsemblRapid:ENSRNOG00000031420 AllianceGenome:RGD:620321
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables hyaluronoglucuronidase activity. Involved in several processes, including hyaluronan catabolic process; positive regulation of urine volume; and renal water absorption. Located in Golgi membrane; membrane raft; and plasma membrane. Biomarker of pulmonary hypertension. Orthologous to human HYAL2 (hyaluronidase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 202.2), Kidney (RPKM 111.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (117121802..117125494)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (108241895..108246853)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (116324062..116328978)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that Hyal2, through direct interactions with CD44 and possibly some pericellular hyaluronidase activity suppresses the formation or the stability of the glycocalyx, modulates ERM-related cytoskeletal interactions, and diminishes cell motility.
Title: Two novel functions of hyaluronidase-2 (Hyal2) are formation of the glycocalyx and control of CD44-ERM interactions.
May degrade hyaluronan by analogy to human HYAL2. Serves as an entry receptor for jaagsiekte sheep retrovirus but not for enzootic nasal tumor virus. Suppresses transformation by the envelope proteins of these viruses in rodent fibroblasts.
Title: Role of virus receptor Hyal2 in oncogenic transformation of rodent fibroblasts by sheep betaretrovirus env proteins.

Submit: New GeneRIF Correction

General gene information

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Markers

BF407105 (e-PCR)
- UniSTS:248589

RH139126 (e-PCR)
- UniSTS:221212

RH142073 (e-PCR)
- UniSTS:224063

AI838527 (e-PCR)
- UniSTS:164418

RH131906 (e-PCR)
- UniSTS:215189

BF387601 (e-PCR)
- UniSTS:244420

UniSTS:236246 (e-PCR)
- UniSTS:236246

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables hyaluronic acid binding	IEA Inferred from Electronic Annotation more info
enables hyaluronic acid binding	ISO Inferred from Sequence Orthology more info
enables hyaluronic acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables hyaluronoglucuronidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hyaluronoglucuronidase activity	IDA Inferred from Direct Assay more info	PubMed
enables hyaluronoglucuronidase activity	IEA Inferred from Electronic Annotation more info
enables hyaluronoglucuronidase activity	ISO Inferred from Sequence Orthology more info
enables hyalurononglucosaminidase activity	IEA Inferred from Electronic Annotation more info
NOT enables hyalurononglucosaminidase activity	ISO Inferred from Sequence Orthology more info
enables hyalurononglucosaminidase activity	ISO Inferred from Sequence Orthology more info
enables hyalurononglucosaminidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables receptor signaling protein tyrosine kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables receptor signaling protein tyrosine kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables receptor signaling protein tyrosine kinase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
contributes_to transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta binding	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta binding	ISO Inferred from Sequence Orthology more info
enables virus receptor activity	IEA Inferred from Electronic Annotation more info
NOT enables virus receptor activity	ISO Inferred from Sequence Orthology more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info
enables virus receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cartilage development	IEA Inferred from Electronic Annotation more info
involved_in cartilage development	ISO Inferred from Sequence Orthology more info
involved_in cartilage development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to UV-B	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV-B	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV-B	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to fibroblast growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to fibroblast growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fibroblast growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to interleukin-1	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in fusion of virus membrane with host plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in fusion of virus membrane with host plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycosaminoglycan catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycosaminoglycan catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in hematopoietic progenitor cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in hyaluronan catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hyaluronan catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hyaluronan catabolic process	IEA Inferred from Electronic Annotation more info
involved_in hyaluronan catabolic process	ISO Inferred from Sequence Orthology more info
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in monocyte activation	IEA Inferred from Electronic Annotation more info
involved_in monocyte activation	ISO Inferred from Sequence Orthology more info
involved_in monocyte activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in multicellular organismal-level iron ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of fibroblast migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-8 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of urine volume	IEP Inferred from Expression Pattern more info	PubMed
involved_in renal water absorption	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to antibiotic	IEA Inferred from Electronic Annotation more info
involved_in response to antibiotic	ISO Inferred from Sequence Orthology more info
involved_in response to reactive oxygen species	IEA Inferred from Electronic Annotation more info
involved_in response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in response to reactive oxygen species	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in skeletal system morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	IDA Inferred from Direct Assay more info	PubMed
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase II transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in endocytic vesicle	IEA Inferred from Electronic Annotation more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
NOT located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in microvillus	IEA Inferred from Electronic Annotation more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: hyaluronidase-2

Names: hyal-2; hyaluronoglucosaminidase 2

NP_742037.2

EC 3.2.1.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.