Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mapk8ip3provided by RGD
Official Full Name: mitogen-activated protein kinase 8 interacting protein 3provided by RGD
Primary source: RGD:1563691
See related: EnsemblRapid:ENSRNOG00000033568 AllianceGenome:RGD:1563691
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: JIP3; JIP-3; JSAP1
Summary: Enables mitogen-activated protein kinase kinase binding activity. Involved in several processes, including anterograde axonal protein transport; axon regeneration; and positive regulation of JNK cascade. Located in several cellular components, including cell body; dendrite; and perinuclear region of cytoplasm. Orthologous to human MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 323.6), Thymus (RPKM 124.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (14422936..14463387, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (13918417..13958335, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (14259394..14299276, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these observations indicate that JIP3 may be involved in transporting vesicular cargoes to the growth cones of PC12 cells, possibly targeting JNK to its substrate paxillin, and thus facilitating neurite outgrowth.
Title: JIP3 localises to exocytic vesicles and focal adhesions in the growth cones of differentiated PC12 cells.
Diabetes seems to change spinal cord KIF5B and SYD mRNA and sciatic nerves KIF5B content and exercise training modifies it, which may be attributable to the training-induced decreased hyperglycemia.
Title: Treadmill training modifies KIF5B motor protein in the STZ-induced diabetic rat spinal cord and sciatic nerve.
JIP3 regulates neuronal axon elongation in a kinesin- and JNK-dependent manner
Title: c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) regulates neuronal axon elongation in a kinesin- and JNK-dependent manner.
JIP1 and JIP3 play important roles in the activation of JNK during simulated ischemia-reperfusion challenge in H9c2 cells.
Title: Regulation of stress-associated scaffold proteins JIP1 and JIP3 on the c-Jun NH2-terminal kinase in ischemia-reperfusion.
Taken together, these results suggest that JSAP1 regulates cell-cell interactions in PC12h cells specifically in the NGF-induced signaling pathway, and does so by modulating N-cadherin.
Title: Regulation of N-cadherin-based cell-cell interaction by JSAP1 scaffold in PC12h cells.

Submit: New GeneRIF Correction

General gene information

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Markers

BF388024 (e-PCR)
- UniSTS:244803

RH130942 (e-PCR)
- UniSTS:214226

AI235144 (e-PCR)
- UniSTS:250336

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables JUN kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables JUN kinase binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase binding	ISO Inferred from Sequence Orthology more info
enables MAP-kinase scaffold activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP-kinase scaffold activity	IEA Inferred from Electronic Annotation more info
enables MAP-kinase scaffold activity	ISO Inferred from Sequence Orthology more info
enables kinesin binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinesin binding	IEA Inferred from Electronic Annotation more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables kinesin binding	ISS Inferred from Sequence or Structural Similarity more info
enables mitogen-activated protein kinase kinase binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables mitogen-activated protein kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase kinase kinase binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor complex adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in anterograde axonal protein transport	IEA Inferred from Electronic Annotation more info
involved_in anterograde axonal protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterograde axonal protein transport	ISO Inferred from Sequence Orthology more info
involved_in axon development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon development	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
involved_in axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in forebrain development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in lung alveolus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung alveolus development	ISO Inferred from Sequence Orthology more info
involved_in lung morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron migration	ISO Inferred from Sequence Orthology more info
involved_in post-embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in respiratory gaseous exchange by respiratory system	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in axolemma	IEA Inferred from Electronic Annotation more info
located_in axolemma	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in smooth endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in smooth endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-Jun-amino-terminal kinase-interacting protein 3

Names: JNK MAP kinase scaffold protein 3; JNK-interacting protein 3; JNK/SAPK-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100673.2 → NP_001094143.2 C-Jun-amino-terminal kinase-interacting protein 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

B0VXR4, E9PSK7

UniProtKB/TrEMBL

A0A8I6GI46

Related

ENSRNOP00000039682.5, ENSRNOT00000042066.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

14422936..14463387 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006245962.4 → XP_006246024.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform X11

UniProtKB/TrEMBL

A0A8I6GI46

Conserved Domains (3) summary

pfam07926
Location:61 → 167

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam09744
Location:30 → 183

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam16471
Location:385 → 453

JIP_LZII; JNK-interacting protein leucine zipper II
XM_006245958.4 → XP_006246020.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform X7

UniProtKB/TrEMBL

A0A8I6GI46

Conserved Domains (3) summary

pfam07926
Location:61 → 167

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam09744
Location:30 → 183

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam16471
Location:410 → 478

JIP_LZII; JNK-interacting protein leucine zipper II
XM_006245956.4 → XP_006246018.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform X5

UniProtKB/TrEMBL

A0A8I6GI46

Conserved Domains (3) summary

pfam07926
Location:61 → 167

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam09744
Location:30 → 183

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam16471
Location:416 → 484

JIP_LZII; JNK-interacting protein leucine zipper II
XM_006245963.4 → XP_006246025.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform X12

UniProtKB/TrEMBL

A0A8I6GI46

Conserved Domains (3) summary

pfam07926
Location:61 → 167

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam09744
Location:30 → 183

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam16471
Location:380 → 448

JIP_LZII; JNK-interacting protein leucine zipper II
XM_006245961.4 → XP_006246023.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform X10

UniProtKB/TrEMBL

A0A8I6GI46

Conserved Domains (3) summary

pfam07926
Location:61 → 167

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam09744
Location:30 → 183

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam16471
Location:386 → 454

JIP_LZII; JNK-interacting protein leucine zipper II
XM_006245955.5 → XP_006246017.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform X4

See identical proteins and their annotated locations for XP_006246017.1

UniProtKB/TrEMBL

A0A8I6GI46, A0A8L2ULH9, A6HCY7

Related

ENSRNOP00000096061.2, ENSRNOT00000109512.2

Conserved Domains (3) summary

pfam07926
Location:61 → 167

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam09744
Location:30 → 183

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam16471
Location:417 → 485

JIP_LZII; JNK-interacting protein leucine zipper II
XM_006245960.5 → XP_006246022.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform X9

UniProtKB/TrEMBL

A0A8I6GI46

Conserved Domains (3) summary

pfam07926
Location:61 → 167

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam09744
Location:30 → 183

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam16471
Location:393 → 461

JIP_LZII; JNK-interacting protein leucine zipper II
XM_006245954.4 → XP_006246016.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform X2

UniProtKB/TrEMBL

A0A8I6GI46

Conserved Domains (3) summary

pfam07926
Location:61 → 167

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam09744
Location:30 → 183

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam16471
Location:424 → 492

JIP_LZII; JNK-interacting protein leucine zipper II
XM_006245959.5 → XP_006246021.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform X8

UniProtKB/TrEMBL

A0A8I6GI46

Related

ENSRNOP00000082502.2, ENSRNOT00000094258.2

Conserved Domains (3) summary

pfam07926
Location:61 → 167

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam09744
Location:30 → 183

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam16471
Location:394 → 462

JIP_LZII; JNK-interacting protein leucine zipper II
XM_008767567.3 → XP_008765789.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform X3

UniProtKB/TrEMBL

A0A8I6B3P0, A0A8I6GI46

Conserved Domains (3) summary

pfam07926
Location:61 → 167

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam09744
Location:30 → 183

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam16471
Location:419 → 487

JIP_LZII; JNK-interacting protein leucine zipper II
XM_006245957.4 → XP_006246019.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform X6

UniProtKB/TrEMBL

A0A8I6GI46

Conserved Domains (3) summary

pfam07926
Location:61 → 167

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam09744
Location:30 → 183

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam16471
Location:425 → 493

JIP_LZII; JNK-interacting protein leucine zipper II
XM_006245953.4 → XP_006246015.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform X1

UniProtKB/TrEMBL

A0A8I5ZV07, A0A8I6GI46

Conserved Domains (3) summary

pfam07926
Location:61 → 167

TPR_MLP1_2; TPR/MLP1/MLP2-like protein

pfam09744
Location:30 → 183

Jnk-SapK_ap_N; JNK_SAPK-associated protein-1

pfam16471
Location:425 → 493

JIP_LZII; JNK-interacting protein leucine zipper II
XM_008767569.3 → XP_008765791.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform X14

UniProtKB/TrEMBL

A0A8I6GI46

Conserved Domains (2) summary

pfam04871
Location:173 → 296

Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region

pfam16471
Location:163 → 231

JIP_LZII; JNK-interacting protein leucine zipper II
XM_008767568.4 → XP_008765790.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform X13

UniProtKB/TrEMBL

A0A8I6GI46

Conserved Domains (2) summary

pfam04871
Location:225 → 348

Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region

pfam16471
Location:215 → 283

JIP_LZII; JNK-interacting protein leucine zipper II
XM_063268923.1 → XP_063124993.1 C-Jun-amino-terminal kinase-interacting protein 3 isoform X15