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    Akr1b10 aldo-keto reductase family 1, member B10 [ Mus musculus (house mouse) ]

    Gene ID: 67861, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Akr1b10provided by MGI
    Official Full Name
    aldo-keto reductase family 1, member B10provided by MGI
    Primary source
    MGI:MGI:1915111
    See related
    Ensembl:ENSMUSG00000061758 AllianceGenome:MGI:1915111
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Akr1b16; 2310005E10Rik
    Summary
    Predicted to enable geranylgeranyl reductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; and retinal dehydrogenase activity. Located in mitochondrion. Is expressed in adrenal gland. Orthologous to several human genes including AKR1B10 (aldo-keto reductase family 1 member B10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 22.0), adrenal adult (RPKM 21.9) and 27 other tissues See more
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    Genomic context

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    See Akr1b10 in Genome Data Viewer
    Location:
    6 B1; 6 14.93 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (34361182..34373884)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (34384247..34396949)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member B8 Neighboring gene cancer susceptibility candidate 4 pseudogene Neighboring gene RIO kinase 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:34334195-34334304 Neighboring gene aldo-keto reductase family 1, member B7 Neighboring gene aldo-keto reductase family 1, member B7 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of AKR1B16, a novel mouse aldo-keto reductase. Giménez-Dejoz J, et al. Chem Biol Interact, 2017 Oct 1. PMID 28322781
    2. Role of AKR1B10 and AKR1B8 in the pathogenesis of non-alcoholic steatohepatitis (NASH) in mouse. Rajak S, et al. Biochim Biophys Acta Mol Basis Dis, 2022 Apr 1. PMID 34954342
    3. Functional expression of novel human and murine AKR1B genes. Salabei JK, et al. Chem Biol Interact, 2011 May 30. PMID 21276782, Free PMC Article
    4. Sulindac inhibits pancreatic carcinogenesis in LSL-KrasG12D-LSL-Trp53R172H-Pdx-1-Cre mice via suppressing aldo-keto reductase family 1B10 (AKR1B10). Li H, et al. Carcinogenesis, 2013 Sep. PMID 23689354, Free PMC Article
    5. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of AKR1B10 and AKR1B8 in the pathogenesis of non-alcoholic steatohepatitis (NASH) in mouse.
      Title: Role of AKR1B10 and AKR1B8 in the pathogenesis of non-alcoholic steatohepatitis (NASH) in mouse.
    2. AKR1B16 reduced aliphatic and aromatic carbonyl compounds, using NADPH as a cofactor, with moderate or low activity (highest kcat values around 5 min(-1)). AKR1B16 showed poor inhibition with classical AKR inhibitors, tolrestat being the most potent.
      Title: Characterization of AKR1B16, a novel mouse aldo-keto reductase.
    3. Our results demonstrate that sulindac inhibits pancreatic carcinogenesis by the inhibition of Kras protein prenylation by targeting AKR1B10.
      Title: Sulindac inhibits pancreatic carcinogenesis in LSL-KrasG12D-LSL-Trp53R172H-Pdx-1-Cre mice via suppressing aldo-keto reductase family 1B10 (AKR1B10).
    4. AKR1B15 and Akr1b16 genes are expressed as functional proteins in human and murine tissues [Akr1b16]
      Title: Functional expression of novel human and murine AKR1B genes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alcohol dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables all-trans-retinol dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables geranylgeranyl reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables indanol dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables retinal dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    aldo-keto reductase family 1, member B10
    Names
    aldo-keto reductase family 1, member B10 (aldose reductase)
    NP_765986.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172398.3 → NP_765986.3  aldo-keto reductase family 1, member B10

      See identical proteins and their annotated locations for NP_765986.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AK075865, AK082777, BY430637
      Consensus CDS
      CCDS19992.1
      UniProtKB/TrEMBL
      G5E895, Q8BIV6
      Related
      ENSMUSP00000039114.8, ENSMUST00000038383.14
      Conserved Domains (2) summary
      COG0656
      Location:1 → 297
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:9 → 289
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    RNA

    1. NR_149754.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC115767
      Related
      ENSMUST00000139156.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      34361182..34373884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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