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    CYSA cystatin A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818685, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYSA
    Official Full Name
    cystatin A
    Primary source
    TAIR:AT2G40880
    Locus tag
    AT2G40880
    See related
    Araport:AT2G40880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCYSA; cystatin A; FL3-27; T20B5.8; T20B5_8
    Summary
    Encodes a protein with cysteine proteinase inhibitor activity. Overexpression increases tolerance to abiotic stressors (i.e.salt,osmotic, cold stress).
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    Genomic context

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    See CYSA in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    2
    Sequence:
    Chromosome: 2; NC_003071.7 (17057388..17058122)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene disproportionating enzyme 2 Neighboring gene phosphoinositide 4-kinase gamma 1 Neighboring gene protein kinase family protein / protein phosphatase 2C (PP2C) family protein Neighboring gene cytochrome P450, family 98, subfamily A, polypeptide 3 Neighboring gene ncRNA Neighboring gene nodulin MtN21 /EamA-like transporter family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two cysteine proteinase inhibitors from Arabidopsis thaliana, AtCYSa and AtCYSb, increasing the salt, drought, oxidation and cold tolerance. Zhang X, et al. Plant Mol Biol, 2008 Sep. PMID 18523728
    2. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    3. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_129651.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within hyperosmotic response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cystatin A
    NP_181620.1
    • cystatin A (CYSA); FUNCTIONS IN: cysteine-type endopeptidase inhibitor activity; INVOLVED IN: response to abiotic stimulus; LOCATED IN: endomembrane system; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Proteinase inhibitor I25, cystatin, conserved site (InterPro:IPR018073), Proteinase inhibitor I25, cystatin (InterPro:IPR000010), Proteinase inhibitor I25, cystatin, conserved region (InterPro:IPR020381); BEST Arabidopsis thaliana protein match is: cystatin B (TAIR:AT3G12490.2); Has 756 Blast hits to 733 proteins in 101 species: Archae - 0; Bacteria - 2; Metazoa - 32; Fungi - 0; Plants - 716; Viruses - 0; Other Eukaryotes - 6 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      17057388..17058122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129651.4 → NP_181620.1  cystatin A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181620.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22202, Q41906, Q8RXS7, Q9FXN6
      UniProtKB/TrEMBL
      A0A178VXG7, A0A5S9X5Y5
      Conserved Domains (1) summary
      smart00043
      Location:33 → 121
      CY; Cystatin-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q41906.2

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