Grwd1 glutamate-rich WD repeat containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grwd1provided by MGI
Official Full Name: glutamate-rich WD repeat containing 1provided by MGI
Primary source: MGI:MGI:2141989
See related: Ensembl:ENSMUSG00000053801 AllianceGenome:MGI:2141989
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A301; Grwd; Wdr28
Summary: Predicted to enable DNA replication origin binding activity; chromatin binding activity; and histone binding activity. Predicted to be involved in DNA replication; nucleosome organization; and ribosome biogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleolus. Is expressed in embryo. Orthologous to human GRWD1 (glutamate rich WD repeat containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 12.6), limb E14.5 (RPKM 9.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 29.53 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (45474647..45480218, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (45825223..45830994, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GRWD1 Over-Expression Promotes Gastric Cancer Progression by Activating Notch Signaling Pathway via Up-Regulation of ADAM17.
Title: GRWD1 Over-Expression Promotes Gastric Cancer Progression by Activating Notch Signaling Pathway via Up-Regulation of ADAM17.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA replication origin binding	ISO Inferred from Sequence Orthology more info
enables DNA replication origin binding	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA replication	ISO Inferred from Sequence Orthology more info
involved_in DNA replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleosome assembly	ISO Inferred from Sequence Orthology more info
involved_in nucleosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleosome disassembly	ISO Inferred from Sequence Orthology more info
involved_in nucleosome disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribosome biogenesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutamate-rich WD repeat-containing protein 1

Names: glutamate rich WD repeat protein GRWD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001420248.1 → NP_001407177.1 glutamate-rich WD repeat-containing protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC149053

UniProtKB/TrEMBL

Q8K335
NM_001420249.1 → NP_001407178.1 glutamate-rich WD repeat-containing protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC149053

UniProtKB/TrEMBL

Q8BIF7
NM_001420250.1 → NP_001407179.1 glutamate-rich WD repeat-containing protein 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC149053

UniProtKB/TrEMBL

Q8BIF7
NM_153419.2 → NP_700468.2 glutamate-rich WD repeat-containing protein 1

See identical proteins and their annotated locations for NP_700468.2

Status: VALIDATED

Source sequence(s)

BC083143, BQ886252, DT904438

Consensus CDS

CCDS21266.2

UniProtKB/Swiss-Prot

G3UVT6, Q810D6, Q922H3

UniProtKB/TrEMBL

Q5XJZ3

Related

ENSMUSP00000103351.3, ENSMUST00000107723.9

Conserved Domains (4) summary

COG2319
Location:194 → 383

WD40; WD40 repeat [General function prediction only]

pfam12265
Location:44 → 111

CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex

sd00039
Location:218 → 259

7WD40; WD40 repeat [structural motif]

cl02567
Location:206 → 384

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...