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    Mif4gd MIF4G domain containing [ Mus musculus (house mouse) ]

    Gene ID: 69674, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mif4gdprovided by MGI
    Official Full Name
    MIF4G domain containingprovided by MGI
    Primary source
    MGI:MGI:1916924
    See related
    Ensembl:ENSMUSG00000020743 AllianceGenome:MGI:1916924
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110014L05Rik; 2310075G12Rik
    Summary
    Predicted to enable identical protein binding activity and translation activator activity. Predicted to be involved in cap-dependent translational initiation and regulation of translational initiation. Predicted to be located in Golgi apparatus and nucleolus. Predicted to be part of histone mRNA stem-loop binding activity complex. Predicted to be active in cytosol. Is expressed in several structures, including aorta; brain; connective tissue; endocrine gland; and genitourinary system. Orthologous to human MIF4GD (MIF4G domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 121.7), adrenal adult (RPKM 65.9) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mif4gd in Genome Data Viewer
    Location:
    11 E2; 11 80.9 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115498744..115503795, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115607918..115612969, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene nucleoporin 85 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 3 Neighboring gene STARR-seq mESC enhancer starr_31165 Neighboring gene predicted gene, 25364 Neighboring gene STARR-positive B cell enhancer ABC_E7096 Neighboring gene mitchondrial ribosomal protein S7 Neighboring gene solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 Neighboring gene STARR-seq mESC enhancer starr_31166 Neighboring gene STARR-positive B cell enhancer mm9_chr11:115494169-115494470 Neighboring gene STARR-positive B cell enhancer ABC_E8470 Neighboring gene STARR-positive B cell enhancer ABC_E2375 Neighboring gene growth factor receptor bound protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E10730 Neighboring gene STARR-positive B cell enhancer ABC_E7098

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Assembly of the SLIP1-SLBP complex on histone mRNA requires heterodimerization and sequential binding of SLBP followed by SLIP1. Bansal N, et al. Biochemistry, 2013 Jan 22. PMID 23286197, Free PMC Article
    2. Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation. Ansseau E, et al. PLoS One, 2016. PMID 26816005, Free PMC Article
    3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cap-dependent translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone mRNA stem-loop binding complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MIF4G domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243584.1 → NP_001230513.1  MIF4G domain-containing protein isoform 1

      See identical proteins and their annotated locations for NP_001230513.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK150749, AL645470, BQ174854
      Consensus CDS
      CCDS25643.1
      UniProtKB/Swiss-Prot
      Q05CE9, Q3UBZ5, Q7TMH3, Q8R333
      Related
      ENSMUSP00000021087.8, ENSMUST00000021087.14
      Conserved Domains (1) summary
      cl02652
      Location:13 → 179
      MIF4G; MIF4G domain

    2. NM_001243586.1 → NP_001230515.1  MIF4G domain-containing protein isoform 2

      See identical proteins and their annotated locations for NP_001230515.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. Variants 3 and 4 encode isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AL645470
      Consensus CDS
      CCDS56818.1
      UniProtKB/TrEMBL
      A2A9W3

    3. NM_001243587.1 → NP_001230516.1  MIF4G domain-containing protein isoform 2

      See identical proteins and their annotated locations for NP_001230516.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. Variants 3 and 4 encode isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AL645470
      Consensus CDS
      CCDS56818.1
      UniProtKB/TrEMBL
      A2A9W3
      Related
      ENSMUSP00000102115.2, ENSMUST00000106506.8
      Conserved Domains (1) summary
      cl02652
      Location:13 → 160
      MIF4G; MIF4G domain

    4. NM_027162.4 → NP_081438.4  MIF4G domain-containing protein isoform 1

      See identical proteins and their annotated locations for NP_081438.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AK150749, AL645470, BQ174854
      Consensus CDS
      CCDS25643.1
      UniProtKB/Swiss-Prot
      Q05CE9, Q3UBZ5, Q7TMH3, Q8R333
      Related
      ENSMUSP00000102116.3, ENSMUST00000106507.9
      Conserved Domains (1) summary
      cl02652
      Location:13 → 179
      MIF4G; MIF4G domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      115498744..115503795 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249229.4 → XP_011247531.1  MIF4G domain-containing protein isoform X3

      See identical proteins and their annotated locations for XP_011247531.1

      UniProtKB/TrEMBL
      Q8BTE1
      Conserved Domains (1) summary
      cl02652
      Location:16 → 122
      MIF4G; MIF4G domain

    2. XM_036156963.1 → XP_036012856.1  MIF4G domain-containing protein isoform X2

      UniProtKB/TrEMBL
      A2A9W3

    3. XM_036156962.1 → XP_036012855.1  MIF4G domain-containing protein isoform X1

      UniProtKB/Swiss-Prot
      Q05CE9, Q3UBZ5, Q7TMH3, Q8R333
      Conserved Domains (1) summary
      cl02652
      Location:13 → 179
      MIF4G; MIF4G domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UBZ5.1 GenPept UniProtKB/Swiss-Prot:Q3UBZ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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