U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Myt1 myelin transcription factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 17932, updated on 9-Dec-2024

    Summary

    Official Symbol
    Myt1provided by MGI
    Official Full Name
    myelin transcription factor 1provided by MGI
    Primary source
    MGI:MGI:1100535
    See related
    Ensembl:ENSMUSG00000010505 AllianceGenome:MGI:1100535
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nzf2; Nzf2a; Nzf2b; Nztf2
    Summary
    This gene is a member of the myelin transcription factor 1 gene family. The encoded protein, a zinc finger DNA-binding protein, is involved in regulation of oligodendrocyte differentiation and proliferation in the developing central nervous system. The gene product has a role in remyelination through regeneration of oligodendrocyte lineage cells in response to demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
    Expression
    Biased expression in CNS E14 (RPKM 7.7), whole brain E14.5 (RPKM 7.3) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Myt1 in Genome Data Viewer
    Location:
    2 H4; 2 103.77 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (181405099..181469579)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181763332..181827775)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene opioid receptor-like 1 Neighboring gene neuropeptides B/W receptor 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06758 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 Neighboring gene STARR-positive B cell enhancer mm9_chr2:181598872-181599172 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide K

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0835

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    myelin transcription factor 1
    Names
    NZF-2
    neural zinc finger factor 2
    neural zinc finger transcription factor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171615.2NP_001165086.1  myelin transcription factor 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding region, compared to variant 1, resulting in a protein (isoform 3) that maintains the reading frame but is longer at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AL845173
      Consensus CDS
      CCDS50856.1
      UniProtKB/TrEMBL
      B0R0C1
      Related
      ENSMUSP00000079900.5, ENSMUST00000081125.11
      Conserved Domains (3) summary
      pfam01530
      Location:887913
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:604835
      MYT1; Myelin transcription factor 1
      pfam14357
      Location:10451118
      DUF4404; Domain of unknown function (DUF4404)
    2. NM_001171616.2NP_001165087.1  myelin transcription factor 1 isoform 2

      See identical proteins and their annotated locations for NP_001165087.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
      Source sequence(s)
      AL845173
      Consensus CDS
      CCDS50857.1
      UniProtKB/Swiss-Prot
      Q8CFC2
      Related
      ENSMUSP00000104388.3, ENSMUST00000108757.9
      Conserved Domains (3) summary
      TIGR04523
      Location:9571029
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:807835
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:524755
      MYT1; Myelin transcription factor 1
    3. NM_001420423.1NP_001407352.1  myelin transcription factor 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL845173
    4. NM_001420424.1NP_001407353.1  myelin transcription factor 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL845173
    5. NM_008665.5NP_032691.2  myelin transcription factor 1 isoform 1

      See identical proteins and their annotated locations for NP_032691.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AL845173
      Consensus CDS
      CCDS17223.1
      UniProtKB/Swiss-Prot
      B0R0C3, B0R0C4, O08995, Q8CFC2, Q8CFH1
      Related
      ENSMUSP00000104387.2, ENSMUST00000108756.8
      Conserved Domains (3) summary
      TIGR04523
      Location:9951067
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:845873
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:562793
      MYT1; Myelin transcription factor 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      181405099..181469579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159141.1XP_036015034.1  myelin transcription factor 1 isoform X6

      Conserved Domains (3) summary
      TIGR04523
      Location:9991071
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:849877
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:566797
      MYT1; Myelin transcription factor 1
    2. XM_036159150.1XP_036015043.1  myelin transcription factor 1 isoform X8

      Conserved Domains (3) summary
      TIGR04523
      Location:9781050
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:828856
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:545776
      MYT1; Myelin transcription factor 1
    3. XM_036159159.1XP_036015052.1  myelin transcription factor 1 isoform X10

      Conserved Domains (3) summary
      TIGR04523
      Location:907979
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:757785
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:474705
      MYT1; Myelin transcription factor 1
    4. XM_036159155.1XP_036015048.1  myelin transcription factor 1 isoform X9

      Conserved Domains (3) summary
      TIGR04523
      Location:9741046
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:824852
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:541772
      MYT1; Myelin transcription factor 1
    5. XM_006500581.5XP_006500644.2  myelin transcription factor 1 isoform X12

      Conserved Domains (2) summary
      pfam01530
      Location:845873
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:562793
      MYT1; Myelin transcription factor 1
    6. XM_036159123.1XP_036015016.1  myelin transcription factor 1 isoform X3

      Conserved Domains (3) summary
      TIGR04523
      Location:9721044
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:822850
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:562793
      MYT1; Myelin transcription factor 1
    7. XM_036159133.1XP_036015026.1  myelin transcription factor 1 isoform X5

      Conserved Domains (3) summary
      TIGR04523
      Location:9511023
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:801829
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:562793
      MYT1; Myelin transcription factor 1
    8. XM_006500577.5XP_006500640.2  myelin transcription factor 1 isoform X1

      See identical proteins and their annotated locations for XP_006500640.2

      UniProtKB/Swiss-Prot
      B0R0C3, B0R0C4, O08995, Q8CFC2, Q8CFH1
      Conserved Domains (3) summary
      TIGR04523
      Location:9951067
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:845873
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:562793
      MYT1; Myelin transcription factor 1
    9. XM_006500579.5XP_006500642.2  myelin transcription factor 1 isoform X4

      See identical proteins and their annotated locations for XP_006500642.2

      UniProtKB/Swiss-Prot
      Q8CFC2
      Conserved Domains (3) summary
      TIGR04523
      Location:9571029
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:807835
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:524755
      MYT1; Myelin transcription factor 1
    10. XM_006500578.5XP_006500641.1  myelin transcription factor 1 isoform X2

      Conserved Domains (3) summary
      TIGR04523
      Location:10541126
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:904932
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:621852
      MYT1; Myelin transcription factor 1
    11. XM_036159160.1XP_036015053.1  myelin transcription factor 1 isoform X10

      Conserved Domains (3) summary
      TIGR04523
      Location:907979
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:757785
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:474705
      MYT1; Myelin transcription factor 1
    12. XM_036159162.1XP_036015055.1  myelin transcription factor 1 isoform X11

      Conserved Domains (3) summary
      TIGR04523
      Location:884956
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam01530
      Location:734762
      zf-C2HC; Zinc finger, C2HC type
      pfam08474
      Location:474705
      MYT1; Myelin transcription factor 1

    RNA

    1. XR_375392.5 RNA Sequence

    2. XR_004938798.1 RNA Sequence

    3. XR_001781155.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001171680.1: Suppressed sequence

      Description
      NM_001171680.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.