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    Dnali1 dynein, axonemal, light intermediate polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 75563, updated on 4-Jan-2025

    Summary

    Official Symbol
    Dnali1provided by MGI
    Official Full Name
    dynein, axonemal, light intermediate polypeptide 1provided by MGI
    Primary source
    MGI:MGI:1922813
    See related
    Ensembl:ENSMUSG00000042707 AllianceGenome:MGI:1922813
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700023A09Rik
    Summary
    Enables dynein heavy chain binding activity. Involved in sperm flagellum assembly. Located in several cellular components, including ciliary base; filopodium; and sperm flagellum. Is expressed in several structures, including brain ventricle and choroid plexus; choroid invagination; ependyma; epithelium; and testis. Human ortholog(s) of this gene implicated in spermatogenic failure 83. Orthologous to human DNALI1 (dynein axonemal light intermediate chain 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in testis adult (RPKM 82.2), ovary adult (RPKM 7.9) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Dnali1 in Genome Data Viewer
    Location:
    4 D2.2; 4 57.99 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124949131..124959443, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (125055339..125065657, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12930 Neighboring gene R-spondin 1 Neighboring gene predicted gene, 38472 Neighboring gene STARR-positive B cell enhancer ABC_E7987 Neighboring gene guanine nucleotide binding protein nucleolar 2 Neighboring gene STARR-positive B cell enhancer ABC_E6215 Neighboring gene Smad nuclear interacting protein 1 Neighboring gene splicing factor 3a, subunit 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein heavy chain binding  
    enables dynein heavy chain binding PubMed 
    Component Evidence Code Pubs
    located_in 9+2 motile cilium PubMed 
    is_active_in axoneme  
    located_in axoneme PubMed 
    located_in axoneme  
    located_in ciliary base PubMed 
    is_active_in ciliary base  
    located_in cilium PubMed 
    located_in cilium  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in dynein axonemal particle  
    part_of dynein complex  
    located_in filopodium PubMed 
    located_in glial cell projection PubMed 
    located_in motile cilium PubMed 
    located_in motile cilium  
    located_in motile cilium  
    located_in sperm flagellum PubMed 
    located_in sperm flagellum  
    located_in sperm flagellum  

    General protein information

    Preferred Names
    axonemal dynein light intermediate polypeptide 1
    Names
    axonemal dynein light chain (hp28) homolog
    inner dynein arm light chain, axonemal

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175223.5NP_780432.1  axonemal dynein light intermediate polypeptide 1

      See identical proteins and their annotated locations for NP_780432.1

      Status: VALIDATED

      Source sequence(s)
      AL626775
      Consensus CDS
      CCDS18635.1
      UniProtKB/Swiss-Prot
      Q0IIN3, Q147V3, Q8BVN8
      Related
      ENSMUSP00000047783.4, ENSMUST00000036383.4
      Conserved Domains (1) summary
      pfam10211
      Location:66252
      Ax_dynein_light; Axonemal dynein light chain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      124949131..124959443 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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