Eef2 eukaryotic translation elongation factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eef2provided by MGI
Official Full Name: eukaryotic translation elongation factor 2provided by MGI
Primary source: MGI:MGI:95288
See related: Ensembl:ENSMUSG00000034994 AllianceGenome:MGI:95288
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ef-2
Summary: Enables GTPase activity. Acts upstream of or within hematopoietic progenitor cell differentiation and translational elongation. Located in cytoplasm and ribosome. Is active in synapse. Is expressed in brain and neocortex. Human ortholog(s) of this gene implicated in glaucoma; spinocerebellar ataxia type 26; and stomach cancer. Orthologous to human EEF2 (eukaryotic translation elongation factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 1248.0), colon adult (RPKM 810.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (81012465..81018343)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (81176631..81182509)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TNKS1BP1 mediates AECII senescence and radiation induced lung injury through suppressing EEF2 degradation.
Title: TNKS1BP1 mediates AECII senescence and radiation induced lung injury through suppressing EEF2 degradation.
Interaction of lncRNA Gm2044 and EEF2 promotes estradiol synthesis in ovarian follicular granulosa cells.
Title: Interaction of lncRNA Gm2044 and EEF2 promotes estradiol synthesis in ovarian follicular granulosa cells.
eEF2 in the prefrontal cortex promotes excitatory synaptic transmission and social novelty behavior.
Title: eEF2 in the prefrontal cortex promotes excitatory synaptic transmission and social novelty behavior.
Amyloid beta induces Fmr1-dependent translational suppression and hyposynchrony of neural activity via phosphorylation of eIF2alpha and eEF2.
Title: Amyloid beta induces Fmr1-dependent translational suppression and hyposynchrony of neural activity via phosphorylation of eIF2α and eEF2.
The phosphorylation status of eukaryotic elongation factor-2 indicates neural activity in the brain.
Title: The phosphorylation status of eukaryotic elongation factor-2 indicates neural activity in the brain.
Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression.
Title: Fluoxetine regulates eEF2 activity (phosphorylation) via HDAC1 inhibitory mechanism in an LPS-induced mouse model of depression.
Repression of eEF2 kinase improves deficits in novel object recognition memory in aged mice.
Title: Repression of eEF2 kinase improves deficits in novel object recognition memory in aged mice.
PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation.
Title: PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation.
Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes.
Title: Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes.
Myostatin inhibits eEF2K-eEF2 by regulating AMPK to suppress protein synthesis.
Title: Myostatin inhibits eEF2K-eEF2 by regulating AMPK to suppress protein synthesis.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fk92g11.x1 (e-PCR)
- UniSTS:201728

D19S643E (e-PCR)
- UniSTS:150566

M76131 (e-PCR)
- UniSTS:180081

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 5S rRNA binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables lncRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables translation elongation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation elongation factor activity	ISO Inferred from Sequence Orthology more info
enables translation elongation factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytoplasmic translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in translation at postsynapse	ISO Inferred from Sequence Orthology more info
involved_in translational elongation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within translational elongation	IDA Inferred from Direct Assay more info	PubMed
involved_in translational elongation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in aggresome	IEA Inferred from Electronic Annotation more info
located_in aggresome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
NOT located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in ribosome	IDA Inferred from Direct Assay more info	PubMed
located_in ribosome	ISO Inferred from Sequence Orthology more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: elongation factor 2

NP_031933.1

EC 3.6.5.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007907.3 → NP_031933.1 elongation factor 2

See identical proteins and their annotated locations for NP_031933.1

Status: VALIDATED

Source sequence(s)

AC155932

Consensus CDS

CCDS35993.1

UniProtKB/Swiss-Prot

P58252, Q544E4

UniProtKB/TrEMBL

Q3TJZ1, Q3TK17, Q3TX47, Q3UDC8

Related

ENSMUSP00000046101.10, ENSMUST00000047864.11

Conserved Domains (6) summary

cd01885
Location:20 → 233

EF2; Elongation Factor 2 (EF2) in archaea and eukarya

cd01681
Location:574 → 746

aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...

cd04096
Location:742 → 821

eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...

PTZ00416
Location:1 → 858

PTZ00416; elongation factor 2; Provisional

cd03700
Location:394 → 488

EF2_snRNP_like_II; Domain II of elongation factor 2 and C-terminal domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein

cd16261
Location:503 → 574

EF2_snRNP_III; Domain III of Elongation Factor 2 (EF2)