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    Tcaf1 TRPM8 channel-associated factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 77574, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tcaf1provided by MGI
    Official Full Name
    TRPM8 channel-associated factor 1provided by MGI
    Primary source
    MGI:MGI:1914665
    See related
    Ensembl:ENSMUSG00000036667 AllianceGenome:MGI:1914665
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam115a; 2810407D09Rik; 3321401G04Rik; A230020K05Rik
    Summary
    Predicted to enable transmembrane transporter binding activity. Predicted to be involved in negative regulation of cell migration; positive regulation of anion channel activity; and positive regulation of protein targeting to membrane. Predicted to be active in plasma membrane. Is expressed in nervous system and neural retina. Orthologous to human TCAF1 (TRPM8 channel associated factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 35.3), CNS E14 (RPKM 32.0) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tcaf1 in Genome Data Viewer
    Location:
    6 B2.1; 6 20.84 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (42644933..42687065, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (42667999..42710131, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene TRPM8 channel-associated factor 3 Neighboring gene TRPM8 channel-associated factor 2 Neighboring gene STARR-seq mESC enhancer starr_15722 Neighboring gene olfactory receptor family 2 subfamily AR member 1, pseudogene 1 Neighboring gene 40S ribosomal protein S23 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity. Gkika D, et al. J Cell Biol, 2015 Jan 5. PMID 25559186, Free PMC Article
    2. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    5. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Report novel TRP channel-associated factors that modulate TRPM8 activity.
      Title: TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0738

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of anion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TRPM8 channel-associated factor 1
    Names
    TRP channel-associated factor 1
    family with sequence similarity 115, member A
    protein FAM115A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355768.1 → NP_001342697.1  TRPM8 channel-associated factor 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK014379, AK132148, BM117796
      UniProtKB/Swiss-Prot
      Q6A005, Q80VG2, Q8BNE1, Q8BPR4, Q8BTD3, Q8C8Q5, Q8CEM1, Q8CET9, Q8K2D7, Q9D223
      Conserved Domains (2) summary
      pfam13402
      Location:633 → 892
      Peptidase_M60; Peptidase M60, enhancin and enhancin-like
      pfam17291
      Location:522 → 631
      M60-like_N; N-terminal domain of M60-like peptidases

    2. NM_001355769.1 → NP_001342698.1  TRPM8 channel-associated factor 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC155334
      Consensus CDS
      CCDS20076.1
      Related
      ENSMUSP00000046137.5, ENSMUST00000045054.11
      Conserved Domains (2) summary
      pfam13402
      Location:633 → 892
      Peptidase_M60; Peptidase M60, enhancin and enhancin-like
      pfam17291
      Location:522 → 631
      M60-like_N; N-terminal domain of M60-like peptidases

    3. NM_001355770.1 → NP_001342699.1  TRPM8 channel-associated factor 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC155334
      Consensus CDS
      CCDS20076.1
      Conserved Domains (2) summary
      pfam13402
      Location:633 → 892
      Peptidase_M60; Peptidase M60, enhancin and enhancin-like
      pfam17291
      Location:522 → 631
      M60-like_N; N-terminal domain of M60-like peptidases

    4. NM_029930.3 → NP_084206.1  TRPM8 channel-associated factor 1 isoform 2

      See identical proteins and their annotated locations for NP_084206.1

      Status: VALIDATED

      Source sequence(s)
      AK053509, BY324097
      Consensus CDS
      CCDS20076.1
      UniProtKB/Swiss-Prot
      Q8BNE1
      Related
      ENSMUSP00000036379.5, ENSMUST00000045140.5
      Conserved Domains (2) summary
      pfam13402
      Location:633 → 892
      Peptidase_M60; Peptidase M60, enhancin and enhancin-like
      pfam17291
      Location:522 → 631
      M60-like_N; N-terminal domain of M60-like peptidases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      42644933..42687065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506752.4 → XP_006506815.1  TRPM8 channel-associated factor 1 isoform X1

      See identical proteins and their annotated locations for XP_006506815.1

      UniProtKB/Swiss-Prot
      Q6A005, Q80VG2, Q8BNE1, Q8BPR4, Q8BTD3, Q8C8Q5, Q8CEM1, Q8CET9, Q8K2D7, Q9D223
      Conserved Domains (2) summary
      pfam13402
      Location:633 → 892
      Peptidase_M60; Peptidase M60, enhancin and enhancin-like
      pfam17291
      Location:522 → 631
      M60-like_N; N-terminal domain of M60-like peptidases

    2. XM_006506754.4 → XP_006506817.1  TRPM8 channel-associated factor 1 isoform X1

      See identical proteins and their annotated locations for XP_006506817.1

      UniProtKB/Swiss-Prot
      Q6A005, Q80VG2, Q8BNE1, Q8BPR4, Q8BTD3, Q8C8Q5, Q8CEM1, Q8CET9, Q8K2D7, Q9D223
      Conserved Domains (2) summary
      pfam13402
      Location:633 → 892
      Peptidase_M60; Peptidase M60, enhancin and enhancin-like
      pfam17291
      Location:522 → 631
      M60-like_N; N-terminal domain of M60-like peptidases

    3. XM_036152394.1 → XP_036008287.1  TRPM8 channel-associated factor 1 isoform X2

      Conserved Domains (2) summary
      pfam13402
      Location:633 → 892
      Peptidase_M60; Peptidase M60, enhancin and enhancin-like
      pfam17291
      Location:522 → 631
      M60-like_N; N-terminal domain of M60-like peptidases

    4. XM_006506753.5 → XP_006506816.1  TRPM8 channel-associated factor 1 isoform X1

      See identical proteins and their annotated locations for XP_006506816.1

      UniProtKB/Swiss-Prot
      Q6A005, Q80VG2, Q8BNE1, Q8BPR4, Q8BTD3, Q8C8Q5, Q8CEM1, Q8CET9, Q8K2D7, Q9D223
      Conserved Domains (2) summary
      pfam13402
      Location:633 → 892
      Peptidase_M60; Peptidase M60, enhancin and enhancin-like
      pfam17291
      Location:522 → 631
      M60-like_N; N-terminal domain of M60-like peptidases

    5. XM_006506756.4 → XP_006506819.1  TRPM8 channel-associated factor 1 isoform X2

      See identical proteins and their annotated locations for XP_006506819.1

      UniProtKB/Swiss-Prot
      Q8BNE1
      Related
      ENSMUSP00000114036.2, ENSMUST00000121083.8
      Conserved Domains (2) summary
      pfam13402
      Location:633 → 892
      Peptidase_M60; Peptidase M60, enhancin and enhancin-like
      pfam17291
      Location:522 → 631
      M60-like_N; N-terminal domain of M60-like peptidases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BNE1.1 GenPept UniProtKB/Swiss-Prot:Q8BNE1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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