Kank4 KN motif and ankyrin repeat domains 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kank4provided by MGI
Official Full Name: KN motif and ankyrin repeat domains 4provided by MGI
Primary source: MGI:MGI:3043381
See related: Ensembl:ENSMUSG00000035407 AllianceGenome:MGI:3043381
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ankrd38; C130031J23
Summary: Predicted to be involved in negative regulation of actin filament polymerization. Predicted to act upstream of or within negative regulation of stress fiber assembly. Predicted to be located in cytosol and microtubule cytoskeleton. Predicted to be active in cytoplasm and cytoskeleton. Is expressed in extrinsic ocular muscle; lung; metanephros; and ureteric tip. Orthologous to human KANK4 (KN motif and ankyrin repeat domains 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in lung adult (RPKM 4.5), limb E14.5 (RPKM 4.3) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C6; 4 45.6 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (98643129..98706295, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (98754892..98818058, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KANK4 Promotes Arteriogenesis by Potentiating VEGFR2 Signaling in a TALIN-1-Dependent Manner.
Title: KANK4 Promotes Arteriogenesis by Potentiating VEGFR2 Signaling in a TALIN-1-Dependent Manner.
Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins.
Title: Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234968

NoName (e-PCR)
- UniSTS:234973

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in negative regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: KN motif and ankyrin repeat domain-containing protein 4

Names: ankyrin repeat domain 38; ankyrin repeat domain-containing protein 38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172872.3 → NP_766460.2 KN motif and ankyrin repeat domain-containing protein 4

See identical proteins and their annotated locations for NP_766460.2

Status: VALIDATED

Source sequence(s)

AL670941

Consensus CDS

CCDS18379.1

UniProtKB/Swiss-Prot

Q6P9J5, Q8BV03

Related

ENSMUSP00000099851.4, ENSMUST00000102790.4

Conserved Domains (6) summary

cd00204
Location:833 → 964

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12075
Location:24 → 62

KN_motif; KN motif

pfam12796
Location:843 → 941

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:808 → 859

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:930 → 985

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:838 → 870

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

98643129..98706295 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011240522.3 → XP_011238824.1 KN motif and ankyrin repeat domain-containing protein 4 isoform X1

See identical proteins and their annotated locations for XP_011238824.1

Conserved Domains (5) summary

sd00045
Location:838 → 877

ANK; ANK repeat [structural motif]

pfam12075
Location:24 → 62

KN_motif; KN motif

pfam12796
Location:922 → 1008

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:808 → 859

Ank_4; Ankyrin repeats (many copies)

pfam18595
Location:328 → 408

DHR10; Designed helical repeat protein 10 domain
XM_011240523.4 → XP_011238825.1 KN motif and ankyrin repeat domain-containing protein 4 isoform X1

See identical proteins and their annotated locations for XP_011238825.1

Conserved Domains (5) summary

sd00045
Location:838 → 877

ANK; ANK repeat [structural motif]

pfam12075
Location:24 → 62

KN_motif; KN motif

pfam12796
Location:922 → 1008

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:808 → 859

Ank_4; Ankyrin repeats (many copies)

pfam18595
Location:328 → 408

DHR10; Designed helical repeat protein 10 domain