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    HEXO2 beta-hexosaminidase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837064, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HEXO2
    Official Full Name
    beta-hexosaminidase 2
    Primary source
    TAIR:AT1G05590
    Locus tag
    AT1G05590
    See related
    Araport:AT1G05590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATHEX3; beta-hexosaminidase 2; BETA-HEXOSAMINIDASE 3; F3F20.4; F3F20_4
    Summary
    Encodes a protein with beta-hexosaminidase activity (the enzyme is active with p-nitrophenyl-beta-N-acetylglucosaminide as substrate but displayed only a minor activity toward p-nitrophenyl-beta-N-acetylgalactosaminide). Chitotriose-PA was digested almost completely overnight by a 50% ammonium sulfate fraction of a supernatant yeast expressing AtHEX3.
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    Genomic context

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    See HEXO2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (1669350..1671902)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene UPSTREAM OF FLC protein (DUF966) Neighboring gene cation/H+ exchanger 23 Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene ADP-glucose pyrophosphorylase small subunit 2 Neighboring gene B3 domain protein (DUF313)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enzymatic properties and subcellular localization of Arabidopsis beta-N-acetylhexosaminidases. Strasser R, et al. Plant Physiol, 2007 Sep. PMID 17644627, Free PMC Article
    2. Biosynthesis of truncated N-linked oligosaccharides results from non-orthologous hexosaminidase-mediated mechanisms in nematodes, plants, and insects. Gutternigg M, et al. J Biol Chem, 2007 Sep 21. PMID 17636254, Free PMC Article
    3. The activity of Arabidopsis glycosyltransferases toward salicylic acid, 4-hydroxybenzoic acid, and other benzoates. Lim EK, et al. J Biol Chem, 2002 Jan 4. PMID 11641410
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_001331557.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables UDP-glucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-N-acetylhexosaminidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hexosaminidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-hexosaminidase 2
    NP_001318927.1
    • beta-hexosaminidase 2 (HEXO2); FUNCTIONS IN: UDP-glucosyltransferase activity, hexosaminidase activity, beta-N-acetylhexosaminidase activity, hydrolase activity, hydrolyzing O-glycosyl compounds; INVOLVED IN: carbohydrate metabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Glycoside hydrolase, family 20, catalytic core (InterPro:IPR015883), Beta-N-acetylhexosaminidase, subunit a/b (InterPro:IPR015882), Glycoside hydrolase, catalytic core (InterPro:IPR017853), Glycoside hydrolase, family 20 (InterPro:IPR001540), Glycoside hydrolase, subgroup, catalytic core (InterPro:IPR013781); BEST Arabidopsis thaliana protein match is: beta-hexosaminidase 1 (TAIR:AT3G55260.1); Has 3806 Blast hits to 3725 proteins in 709 species: Archae - 2; Bacteria - 2403; Metazoa - 477; Fungi - 234; Plants - 128; Viruses - 0; Other Eukaryotes - 562 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      1669350..1671902
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001331558.1 → NP_001323090.1  beta-hexosaminidase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SYK0
      UniProtKB/TrEMBL
      A0A178WKV1, A0A5S9ST94, A0A654E8B5
      Conserved Domains (2) summary
      cd06562
      Location:171 → 552
      GH20_HexA_HexB-like; Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the ...
      pfam14845
      Location:33 → 149
      Glycohydro_20b2; beta-acetyl hexosaminidase like

    2. NM_100439.3 → NP_172050.1  beta-hexosaminidase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172050.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SYK0
      UniProtKB/TrEMBL
      A0A178WKV1, A0A5S9ST94, A0A654E8B5
      Conserved Domains (2) summary
      cd06562
      Location:171 → 552
      GH20_HexA_HexB-like; Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the ...
      pfam14845
      Location:33 → 149
      Glycohydro_20b2; beta-acetyl hexosaminidase like

    3. NM_001331557.1 → NP_001318927.1  beta-hexosaminidase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SYK0
      UniProtKB/TrEMBL
      A0A178WKV1, A0A5S9ST94, A0A654E8B5
      Conserved Domains (2) summary
      cd06562
      Location:171 → 552
      GH20_HexA_HexB-like; Beta-N-acetylhexosaminidases catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. The hexA and hexB genes encode the ...
      pfam14845
      Location:33 → 149
      Glycohydro_20b2; beta-acetyl hexosaminidase like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SYK0.1

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