NHX5 sodium hydrogen exchanger 5 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: NHX5
Official Full Name: sodium hydrogen exchanger 5
Primary source: TAIR:AT1G54370
Locus tag: AT1G54370
See related: Araport:AT1G54370
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATNHX5; F20D21.19; F20D21_19; NA+/H+ ANTIPORTER 5; sodium hydrogen exchanger 5
Summary: Encodes an endosomal Na(+)/H(+) antiporter: AT1G54370 (NHX5), AT1G79610 (NHX6). Double knockout nhx5 nhx6 showed reduced growth, with smaller and fewer cells and increased sensitivity to salinity.
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Genomic context

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See NHX5 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 21

Sequence:: Chromosome: 1; NC_003070.9 (20293151..20297236, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

double knockout of NHX5 and NHX6 results in the impairment of endosome motility and protein recycling at the trans-Golgi network/early endosome, but not in the secretion of integral membrane protein
Title: NHX-type Na(+)(K(+))/H(+) antiporters are required for TGN/EE trafficking and endosomal ion homeostasis in Arabidopsis thaliana.
regulates the pH of endoplasmic reticulum and auxin-mediated development
Title: Na(+) ,K(+) /H(+) antiporters regulate the pH of endoplasmic reticulum and auxin-mediated development.
AtNHX5 and AtNHX6 regulate the trafficking of seed storage proteins into the vacuole; the H(+) leak pathway conducted by AtNHX5 and AtNHX6 is critical for protein transport.
Title: AtNHX5 and AtNHX6: Roles in protein transport.
Study shows that NHX5 and NHX6 are necessary for processing of the predominant seed storage proteins, and also influence the processing and activity of a vacuolar processing enzyme.
Title: Arabidopsis Intracellular NHX-Type Sodium-Proton Antiporters are Required for Seed Storage Protein Processing.
required for protein storage vacuole localization of the SNARE complex and its function in protein transport
Title: AtNHX5 and AtNHX6 Are Required for the Subcellular Localization of the SNARE Complex That Mediates the Trafficking of Seed Storage Proteins in Arabidopsis.
NHX5 and NHX6 are putative endosomal Na+ (K+)/H+ antiporters expressed throughout plant development. They are are functionally redundant and play key roles in cell proliferation and cell growth.
Title: The Arabidopsis intracellular Na+/H+ antiporters NHX5 and NHX6 are endosome associated and necessary for plant growth and development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_104315.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables sodium ion transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables sodium:proton antiporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lithium ion transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of pH	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sodium ion transport	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sodium hydrogen exchanger 5

NP_175839.2

sodium hydrogen exchanger 5 (NHX5); FUNCTIONS IN: sodium:hydrogen antiporter activity, sodium ion transmembrane transporter activity; INVOLVED IN: lithium ion transport, sodium ion transport; LOCATED IN: integral to membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Na+/H+ exchanger, subfamily (InterPro:IPR004709), Na+/H+ exchanger, isoform 5/6/8, conserved region (InterPro:IPR018409), Cation/H+ exchanger, conserved region (InterPro:IPR018422), Cation/H+ exchanger (InterPro:IPR006153); BEST Arabidopsis thaliana protein match is: Na+/H+ antiporter 6 (TAIR:AT1G79610.1); Has 6647 Blast hits to 6641 proteins in 1771 species: Archae - 114; Bacteria - 4554; Metazoa - 890; Fungi - 160; Plants - 421; Viruses - 0; Other Eukaryotes - 508 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

20293151..20297236 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_104315.5 → NP_175839.2 sodium hydrogen exchanger 5 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_175839.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0WWC0, Q8S396, Q9SLJ7

UniProtKB/TrEMBL

A0A5S9WPV6, A0A654EIX1

Conserved Domains (1) summary

COG0025
Location:22 → 413

NhaP; NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]