RPSA ribosomal protein SA [Homo sapiens (human)] - Gene

Summary

Official Symbol: RPSAprovided by HGNC
Official Full Name: ribosomal protein SAprovided by HGNC
Primary source: HGNC:HGNC:6502
See related: Ensembl:ENSG00000168028 MIM:150370; AllianceGenome:HGNC:6502
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SA; LBP; LRP; p40; uS2; 67LR; ICAS; lamR; 37LRP; LAMBR; LAMR1; LRP/LR; LBP/p40; NEM/1CHD4
Summary: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in ovary (RPKM 792.7), lymph node (RPKM 583.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3p22.1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (39406720..39412542)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (39419647..39425467)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (39448211..39454033)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Laminin receptor 1 expression in premalignant and malignant squamous lesions of the cervix.
Title: Laminin receptor 1 expression in premalignant and malignant squamous lesions of the cervix.
Ribosomal protein SA is a common component of neuronal intranuclear inclusions in polyglutamine diseases and Marinesco bodies.
Title: Ribosomal protein SA is a common component of neuronal intranuclear inclusions in polyglutamine diseases and Marinesco bodies.
LAMR1 restricts Zika virus infection by attenuating the envelope protein ubiquitination.
Title: LAMR1 restricts Zika virus infection by attenuating the envelope protein ubiquitination.
The role of LR-TIMAP/PP1c complex in the occurrence and development of no-reflow.
Title: The role of LR-TIMAP/PP1c complex in the occurrence and development of no-reflow.
AG-9, an Elastin-Derived Peptide, Increases In Vitro Oral Tongue Carcinoma Cell Invasion, through an Increase in MMP-2 Secretion and MT1-MMP Expression, in a RPSA-Dependent Manner.
Title: AG-9, an Elastin-Derived Peptide, Increases In Vitro Oral Tongue Carcinoma Cell Invasion, through an Increase in MMP-2 Secretion and MT1-MMP Expression, in a RPSA-Dependent Manner.
Mutations in RPSA and NKX2-3 link development of the spleen and intestinal vasculature.
Title: Mutations in RPSA and NKX2-3 link development of the spleen and intestinal vasculature.
MicroRNA-587 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Targeting Ribosomal Protein SA.
Title: MicroRNA-587 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Targeting Ribosomal Protein SA.
Dentate gyrus volume deficit in schizophrenia.
Title: Dentate gyrus volume deficit in schizophrenia.
Identification of the Neuroinvasive Pathogen Host Target, LamR, as an Endothelial Receptor for the Treponema pallidum Adhesin Tp0751.
Title: Identification of the Neuroinvasive Pathogen Host Target, LamR, as an Endothelial Receptor for the Treponema pallidum Adhesin Tp0751.
LRP::FLAG Rescues Cells from Amyloid-beta-Mediated Cytotoxicity Through Increased TERT Levels and Telomerase Activity.
Title: LRP::FLAG Rescues Cells from Amyloid-β-Mediated Cytotoxicity Through Increased TERT Levels and Telomerase Activity.

Submit: New GeneRIF Correction See all GeneRIFs (90)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Familial isolated congenital asplenia MedGen: C0685889 OMIM: 271400 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Rev	rev	HIV-1 Rev interacting protein, ribosomal protein SA (RPSA), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S813E (e-PCR)
- UniSTS:473359

D11S813E (e-PCR)
- UniSTS:473360

D3S3955 (e-PCR)
- UniSTS:51996

RP_SA_1 (e-PCR)
- UniSTS:51997

D11S813E (e-PCR)
- UniSTS:150069

NoName (e-PCR)
- UniSTS:148286

RH92628 (e-PCR)
- UniSTS:91732

D11S813E (e-PCR)
- UniSTS:154710

G59752 (e-PCR)
- UniSTS:137048

LAMR1_459 (e-PCR)
- UniSTS:277445

REN116494 (e-PCR)
- UniSTS:441289

REN116495 (e-PCR)
- UniSTS:441290

fa91h01.x1 (e-PCR)
- UniSTS:189647

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	HDA more info	PubMed
enables laminin binding	IEA Inferred from Electronic Annotation more info
enables laminin receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosome binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of ribosome	HDA more info	PubMed
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed
enables virus receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic translation	IC Inferred by Curator more info	PubMed
involved_in cytoplasmic translation	NAS Non-traceable Author Statement more info	PubMed
involved_in ribosomal small subunit assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info
involved_in translation	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in cytosolic ribosome	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic small ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic small ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic small ribosomal subunit	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in membrane	HDA more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: small ribosomal subunit protein uS2

Names: 37 kDa laminin receptor; 37/67 kDa laminin receptor; 40S ribosomal protein SA; 67 kDa laminin receptor; colon carcinoma laminin-binding protein; laminin receptor 1 (67kD, ribosomal protein SA); laminin-binding protein precursor p40; multidrug resistance-associated protein MGr1-Ag

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_033234.1 RefSeqGene

Range

5008..10830

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_735

mRNA and Protein(s)

NM_001304288.2 → NP_001291217.1 small ribosomal subunit protein uS2 isoform 2

See identical proteins and their annotated locations for NP_001291217.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is longer compared to isoform 1.

Source sequence(s)

BC070263, BC071968, BM999786, X15005

Consensus CDS

CCDS77723.1

UniProtKB/TrEMBL

A0A0C4DG17, Q96RS2

Related

ENSP00000389351.1, ENST00000443003.2

Conserved Domains (1) summary

PTZ00254
Location:1 → 255

PTZ00254; 40S ribosomal protein SA; Provisional
NM_002295.6 → NP_002286.2 small ribosomal subunit protein uS2 isoform 1

See identical proteins and their annotated locations for NP_002286.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).

Source sequence(s)

BC070263, BC071968, BM999786

Consensus CDS

CCDS2686.1

UniProtKB/Swiss-Prot

P08865, P11085, P12030, Q16471, Q6IPD1, Q6IPD2, Q6NSD1, Q6NXQ8, Q86VC0

UniProtKB/TrEMBL

Q96RS2

Related

ENSP00000346067.4, ENST00000301821.11

Conserved Domains (1) summary

PTZ00254
Location:1 → 250

PTZ00254; 40S ribosomal protein SA; Provisional