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    CXXS1 C-terminal cysteine residue is changed to a serine 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837696, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CXXS1
    Official Full Name
    C-terminal cysteine residue is changed to a serine 1
    Primary source
    TAIR:AT1G11530
    Locus tag
    AT1G11530
    See related
    Araport:AT1G11530
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCXXS1; C-terminal cysteine residue is changed to a serine 1
    Summary
    Encodes a monocysteinic thioredoxin, thioredoxin in which the second cysteine of the redox site is replaced by a serine, with low disulfide reductase but efficient disulfide isomerase activity.
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    Genomic context

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    See CXXS1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (3874396..3875484)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene DNA-binding storekeeper protein-related transcriptional regulator Neighboring gene pliceosome associated protein-like protein Neighboring gene ncRNA Neighboring gene Sulfite exporter TauE/SafE family protein Neighboring gene xyloglucan endotransglucosylase/hydrolase 8 Neighboring gene tRNA-Leu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtCXXS: atypical members of the Arabidopsis thaliana thioredoxin h family with a remarkably high disulfide isomerase activity. Serrato AJ, et al. Physiol Plant, 2008 Jul. PMID 18384502
    2. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_101026.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in protein deglutathionylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region HDA PubMed 

    General protein information

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    Preferred Names
    C-terminal cysteine residue is changed to a serine 1
    NP_172620.1
    • C-terminal cysteine residue is changed to a serine 1 (CXXS1); CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin, core (InterPro:IPR015467), Thioredoxin-like (InterPro:IPR017936), Thioredoxin domain (InterPro:IPR013766), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: thioredoxin H-type 1 (TAIR:AT3G51030.1); Has 9365 Blast hits to 9347 proteins in 2322 species: Archae - 165; Bacteria - 5071; Metazoa - 947; Fungi - 584; Plants - 1098; Viruses - 0; Other Eukaryotes - 1500 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3874396..3875484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101026.3 → NP_172620.1  C-terminal cysteine residue is changed to a serine 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172620.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2HIL3, Q8LDI5, Q9SYX9, Q9XH49
      UniProtKB/TrEMBL
      A0A178WIW7, A0A5S9TVM1
      Conserved Domains (1) summary
      cd02947
      Location:11 → 106
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LDI5.2

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