CYCA2;3 CYCLIN A2;3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CYCA2;3
Official Full Name: CYCLIN A2;3
Primary source: TAIR:AT1G15570
Locus tag: AT1G15570
See related: Araport:AT1G15570
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: CYCLIN A2;3; T16N11.8; T16N11_8
Summary: A2-type cyclin. Negatively regulates endocycles and acts as a key regulator of ploidy levels in Arabidopsis endoreduplication. Interacts physically with CDKA;1. Expressed preferentially in trichomes and young developing tissues.
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Genomic context

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See CYCA2;3 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 11

Sequence:: Chromosome: 1; NC_003070.9 (5361865..5365559)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CCS52A1 participates in endocycle onset by down-regulating CDKB1;1 activity through the destruction of CYCA2;3.
Title: CDKB1;1 forms a functional complex with CYCA2;3 to suppress endocycle onset.
CYCA2;3 negatively regulates endocycles and acts as a key regulator of ploidy levels in Arabidopsis endoreduplication
Title: The A-type cyclin CYCA2;3 is a key regulator of ploidy levels in Arabidopsis endoreduplication.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_101426.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell cycle G2/M phase transition	IGI Inferred from Genetic Interaction more info	PubMed
involved_in guard mother cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lateral root formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitotic cell cycle phase transition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of stomatal complex development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of G2/M transition of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CYCLIN A2;3

NP_173010.1

CYCLIN A2;3 (CYCA2;3); CONTAINS InterPro DOMAIN/s: Cyclin, C-terminal (InterPro:IPR004367), Cyclin (InterPro:IPR006670), G2/mitotic-specific cyclin A (InterPro:IPR015453), Cyclin-like (InterPro:IPR011028), Cyclin-related (InterPro:IPR013763), Cyclin, N-terminal (InterPro:IPR006671), Cyclin, A/B/D/E (InterPro:IPR014400); BEST Arabidopsis thaliana protein match is: Cyclin A2;4 (TAIR:AT1G80370.1); Has 4146 Blast hits to 4144 proteins in 368 species: Archae - 0; Bacteria - 0; Metazoa - 1906; Fungi - 532; Plants - 1053; Viruses - 34; Other Eukaryotes - 621 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

5361865..5365559

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_101426.5 → NP_173010.1 CYCLIN A2;3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_173010.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q38819, Q8VYG1, Q9M9D7

UniProtKB/TrEMBL

A0A178WNJ4, A0A5S9UMN1, A0A7G2DVP1

Conserved Domains (2) summary

cd20506
Location:320 → 434

CYCLIN_AtCycA-like_rpt2; second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins

cd20562
Location:181 → 316

CYCLIN_AtCycA_like_rpt1; first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins