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    FLN2 fructokinase-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843251, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FLN2
    Official Full Name
    fructokinase-like protein
    Primary source
    TAIR:AT1G69200
    Locus tag
    AT1G69200
    See related
    Araport:AT1G69200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F4N2.16; F4N2_16; fructokinase-like 2
    Summary
    Encodes a fructokinase-like protein (AT3G54090/FLN1, AT1G69200/FLN2), a member of the pfkB-carbohydrate kinase family. FLN1 and FLN2 are potential plastidial thioredoxin z (TRX z) targets. Mutants display mutant chloroplast development, general plant growth and development defects and defects in PEP-dependent transcription.
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    Genomic context

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    See FLN2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (26016024..26018365)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Squamosa promoter-binding protein-like (SBP domain) transcription factor family protein Neighboring gene Plant-specific transcription factor YABBY family protein Neighboring gene Dihydropterin pyrophosphokinase / Dihydropteroate synthase Neighboring gene Uncharacterized protein family UPF0090 Neighboring gene Protein kinase superfamily protein Neighboring gene SPIRAL1-like2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rubisco accumulation is important for the greening of the fln2-4 mutant in Arabidopsis. Huang C, et al. Plant Sci, 2015 Jul. PMID 26025532
    2. Arabidopsis fructokinase-like protein associations are regulated by ATP. Riggs JW, et al. Biochem J, 2017 May 10. PMID 28377494
    3. The plastid-localized pfkB-type carbohydrate kinases FRUCTOKINASE-LIKE 1 and 2 are essential for growth and development of Arabidopsis thaliana. Gilkerson J, et al. BMC Plant Biol, 2012 Jul 8. PMID 22770232, Free PMC Article
    4. The reduced plastid-encoded polymerase-dependent plastid gene expression leads to the delayed greening of the Arabidopsis fln2 mutant. Huang C, et al. PLoS One, 2013. PMID 24019900, Free PMC Article
    5. Plastidial thioredoxin z interacts with two fructokinase-like proteins in a thiol-dependent manner: evidence for an essential role in chloroplast development in Arabidopsis and Nicotiana benthamiana. Arsova B, et al. Plant Cell, 2010 May. PMID 20511297, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that, at ATP concentrations that promote FLN1 homomeric interactions, the FLN1-FLN2 hetero-oligomer is dominant form in vitro; FLN1 associates with a large protein complex in chloroplasts independent of ATP.
      Title: Arabidopsis fructokinase-like protein associations are regulated by ATP.
    2. The Rubisco content in fln2-4 was low, but it rapidly accumulated during the greening of fln2-4. Expression of a nuclear-encoded rbcL gene facilitates Rubisco accumulation and partially complements the mutant defects. These results suggest that the Rubisco accumulation is critical for fln2-4 greening. [FLN2]
      Title: Rubisco accumulation is important for the greening of the fln2-4 mutant in Arabidopsis.
    3. proposed the partial PEP activity in the fln2 mutant allowed plastids to develop into fully functional chloroplasts when exogenous sucrose was supplied, and finally the mutants exhibited green phenotype
      Title: The reduced plastid-encoded polymerase-dependent plastid gene expression leads to the delayed greening of the Arabidopsis fln2 mutant.
    4. FLN1 and FLN2 are essential for growth and development.
      Title: The plastid-localized pfkB-type carbohydrate kinases FRUCTOKINASE-LIKE 1 and 2 are essential for growth and development of Arabidopsis thaliana.
    5. Data strongly suggests an important role for TRX z and both FLNs in the regulation of plastid-encoded RNA polymerase-dependent transcription in chloroplasts. [FLN2]
      Title: Plastidial thioredoxin z interacts with two fructokinase-like proteins in a thiol-dependent manner: evidence for an essential role in chloroplast development in Arabidopsis and Nicotiana benthamiana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_105587.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chloroplast organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within etioplast organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plastid transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plastid transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast nucleoid HDA PubMed 
    located_in chloroplast nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of plastid-encoded plastid RNA polymerase complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fructokinase-like protein
    NP_177080.3
    • fructokinase-like 2 (FLN2); FUNCTIONS IN: kinase activity; INVOLVED IN: acetate fermentation, sucrose biosynthetic process, sucrose catabolic process, using beta-fructofuranosidase; LOCATED IN: chloroplast nucleoid, nucleoid; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Carbohydrate/purine kinase (InterPro:IPR011611); BEST Arabidopsis thaliana protein match is: fructokinase-like 1 (TAIR:AT3G54090.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      26016024..26018365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105587.6 → NP_177080.3  fructokinase-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I0K2, Q9C978, Q9LQA2
      UniProtKB/TrEMBL
      A0A654ENY4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4I0K2.2

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