Ppp6r1 protein phosphatase 6, regulatory subunit 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp6r1provided by MGI
Official Full Name: protein phosphatase 6, regulatory subunit 1provided by MGI
Primary source: MGI:MGI:2442163
See related: Ensembl:ENSMUSG00000052296 AllianceGenome:MGI:2442163
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pp6r1; Saps1; mKIAA1115; 2010309P17Rik; B430201G11Rik; D030074N20Rik
Summary: Predicted to enable protein phosphatase binding activity; protein phosphatase regulator activity; and small GTPase binding activity. Predicted to be involved in regulation of signal transduction. Predicted to be active in cytosol and nucleus. Orthologous to human PPP6R1 (protein phosphatase 6 regulatory subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 137.1), spleen adult (RPKM 65.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 2.68 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (4634494..4661949, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (4631495..4658950, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of the SAPS1 subunit of protein phosphatase 6 in mice increases radiosensitivity and impairs the cellular DNA damage response.
Title: Deletion of the SAPS1 subunit of protein phosphatase 6 in mice increases radiosensitivity and impairs the cellular DNA damage response.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info	PubMed
enables protein phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase regulator activity	ISO Inferred from Sequence Orthology more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase 6 regulatory subunit 1

Names: SAPS domain family, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172894.2 → NP_766482.2 serine/threonine-protein phosphatase 6 regulatory subunit 1

See identical proteins and their annotated locations for NP_766482.2

Status: PROVISIONAL

Source sequence(s)

BC053076

Consensus CDS

CCDS39737.1

UniProtKB/Swiss-Prot

Q7TSI3, Q80TJ4

UniProtKB/TrEMBL

B2RUA5

Related

ENSMUSP00000066736.7, ENSMUST00000064099.8

Conserved Domains (2) summary

PHA03247
Location:719 → 847

PHA03247; large tegument protein UL36; Provisional

pfam04499
Location:128 → 519

SAPS; SIT4 phosphatase-associated protein