Tlr3 toll-like receptor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tlr3provided by MGI
Official Full Name: toll-like receptor 3provided by MGI
Primary source: MGI:MGI:2156367
See related: Ensembl:ENSMUSG00000031639 AllianceGenome:MGI:2156367
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables pattern recognition receptor activity; transmembrane signaling receptor activity; and ubiquitin-like protein ligase binding activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of angiogenesis; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including cellular response to exogenous dsRNA; positive regulation of intracellular signal transduction; and regulation of cytokine production. Is active in plasma membrane. Is expressed in blood; brain; and submandibular gland primordium. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; liver cirrhosis; and primary immunodeficiency disease (multiple). Orthologous to human TLR3 (toll like receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 3.5), large intestine adult (RPKM 1.7) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B1.1; 8 25.31 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (45848702..45864112, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (45395665..45411075, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TLR3/TRIF and MAVS Signaling Is Essential in Regulating Mucosal T Cell Responses during Rotavirus Infection.
Title: TLR3/TRIF and MAVS Signaling Is Essential in Regulating Mucosal T Cell Responses during Rotavirus Infection.
Nucleic acid sensing Toll-like receptors 3 and 9 play complementary roles in the development of bacteremia after nasal colonization associated with influenza co-infection.
Title: Nucleic acid sensing Toll-like receptors 3 and 9 play complementary roles in the development of bacteremia after nasal colonization associated with influenza co-infection.
Motor, Cognitive, and Behavioral Impairment in TLR3 and TLR9 Deficient Male Mice: Insights into the Non-Immunological Roles of Toll-Like Receptors.
Title: Motor, Cognitive, and Behavioral Impairment in TLR3 and TLR9 Deficient Male Mice: Insights into the Non-Immunological Roles of Toll-Like Receptors.
M2 macrophage-derived exosomal miR-26b-5p regulates macrophage polarization and chondrocyte hypertrophy by targeting TLR3 and COL10A1 to alleviate osteoarthritis.
Title: M2 macrophage-derived exosomal miR-26b-5p regulates macrophage polarization and chondrocyte hypertrophy by targeting TLR3 and COL10A1 to alleviate osteoarthritis.
Evaluation of the TLR3 involvement during Schistosoma japonicum-induced pathology.
Title: Evaluation of the TLR3 involvement during Schistosoma japonicum-induced pathology.
Viral-like TLR3 induction of cytokine networks and alpha-synuclein are reduced by complement C3 blockade in mouse brain.
Title: Viral-like TLR3 induction of cytokine networks and α-synuclein are reduced by complement C3 blockade in mouse brain.
Extracellular RNAs-TLR3 signaling contributes to cognitive impairment after chronic neuropathic pain in mice.
Title: Extracellular RNAs-TLR3 signaling contributes to cognitive impairment after chronic neuropathic pain in mice.
TLR3 activation by Clonorchis sinensis infection alleviates the fluke-induced liver fibrosis.
Title: TLR3 activation by Clonorchis sinensis infection alleviates the fluke-induced liver fibrosis.
Toll-Like Receptor 3 Mediates Aortic Stenosis Through a Conserved Mechanism of Calcification.
Title: Toll-Like Receptor 3 Mediates Aortic Stenosis Through a Conserved Mechanism of Calcification.
TLR3 stimulation improves the migratory potency of adipose-derived mesenchymal stem cells through the stress response pathway in the melanoma mouse model.
Title: TLR3 stimulation improves the migratory potency of adipose-derived mesenchymal stem cells through the stress response pathway in the melanoma mouse model.

Submit: New GeneRIF Correction See all GeneRIFs (309)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2)
Endonuclease-mediated (10) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables pattern recognition receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables pattern recognition receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables pattern recognition receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables pattern recognition receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-like protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in I-kappaB phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to exogenous dsRNA	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to exogenous dsRNA	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interferon-beta	IEA Inferred from Electronic Annotation more info
involved_in cellular response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to type II interferon	IEA Inferred from Electronic Annotation more info
involved_in cellular response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to virus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to virus	TAS Traceable Author Statement more info	PubMed
involved_in extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response to wounding	IDA Inferred from Direct Assay more info	PubMed
involved_in inflammatory response to wounding	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	TAS Traceable Author Statement more info	PubMed
acts_upstream_of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of macrophage cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male gonad development	IEA Inferred from Electronic Annotation more info
involved_in microglial cell activation	IEA Inferred from Electronic Annotation more info
involved_in microglial cell activation	ISO Inferred from Sequence Orthology more info
involved_in necroptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in necroptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-alpha production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interferon-beta production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of interleukin-12 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of macrophage cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of type I interferon production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of type III interferon production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of dendritic cell cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in response to dsRNA	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to exogenous dsRNA	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to exogenous dsRNA	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within toll-like receptor 3 signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in toll-like receptor 3 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of type I interferon production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of type III interferon production	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
is_active_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: toll-like receptor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357316.1 → NP_001344245.1 toll-like receptor 3 precursor

Status: VALIDATED

Source sequence(s)

AK083977, AK171438, BC099937

Consensus CDS

CCDS22278.1

UniProtKB/Swiss-Prot

Q91ZM4, Q99MB1

UniProtKB/TrEMBL

Q499F3

Related

ENSMUSP00000147738.2, ENSMUST00000209772.2

Conserved Domains (7) summary

smart00082
Location:646 → 698

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:756 → 901

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:70 → 543

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:589 → 610

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:277 → 300

LRR_RI; leucine-rich repeat [structural motif]

pfam17968
Location:699 → 731

Tlr3_TMD; Toll-like receptor 3 trans-membrane domain

cd21340
Location:503 → 649

PPP1R42; protein phosphatase 1 regulatory subunit 42
NM_001357317.1 → NP_001344246.1 toll-like receptor 3 precursor

Status: VALIDATED

Source sequence(s)

AC116861, AC120003

Consensus CDS

CCDS22278.1

UniProtKB/Swiss-Prot

Q91ZM4, Q99MB1

UniProtKB/TrEMBL

Q499F3

Related

ENSMUSP00000126556.2, ENSMUST00000167106.3

Conserved Domains (7) summary

smart00082
Location:646 → 698

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:756 → 901

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:70 → 543

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:589 → 610

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:277 → 300

LRR_RI; leucine-rich repeat [structural motif]

pfam17968
Location:699 → 731

Tlr3_TMD; Toll-like receptor 3 trans-membrane domain

cd21340
Location:503 → 649

PPP1R42; protein phosphatase 1 regulatory subunit 42
NM_126166.5 → NP_569054.2 toll-like receptor 3 precursor

See identical proteins and their annotated locations for NP_569054.2

Status: VALIDATED

Source sequence(s)

AK083977, BC099937, BY770706

Consensus CDS

CCDS22278.1

UniProtKB/Swiss-Prot

Q91ZM4, Q99MB1

UniProtKB/TrEMBL

Q499F3

Related

ENSMUSP00000034056.5, ENSMUST00000034056.12

Conserved Domains (7) summary

smart00082
Location:646 → 698

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:756 → 901

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:70 → 543

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:589 → 610

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:277 → 300

LRR_RI; leucine-rich repeat [structural motif]

pfam17968
Location:699 → 731

Tlr3_TMD; Toll-like receptor 3 trans-membrane domain

cd21340
Location:503 → 649

PPP1R42; protein phosphatase 1 regulatory subunit 42

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

45848702..45864112 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509279.3 → XP_006509342.1 toll-like receptor 3 isoform X1

See identical proteins and their annotated locations for XP_006509342.1

UniProtKB/Swiss-Prot

Q91ZM4, Q99MB1

UniProtKB/TrEMBL

Q499F3

Conserved Domains (7) summary

smart00082
Location:646 → 698

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:756 → 901

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:70 → 543

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:589 → 610

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:277 → 300

LRR_RI; leucine-rich repeat [structural motif]

pfam17968
Location:699 → 731

Tlr3_TMD; Toll-like receptor 3 trans-membrane domain

cd21340
Location:503 → 649

PPP1R42; protein phosphatase 1 regulatory subunit 42
XM_006509280.4 → XP_006509343.1 toll-like receptor 3 isoform X1

See identical proteins and their annotated locations for XP_006509343.1

UniProtKB/Swiss-Prot

Q91ZM4, Q99MB1

UniProtKB/TrEMBL

Q499F3

Conserved Domains (7) summary

smart00082
Location:646 → 698

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:756 → 901

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:70 → 543

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:589 → 610

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:277 → 300

LRR_RI; leucine-rich repeat [structural motif]

pfam17968
Location:699 → 731

Tlr3_TMD; Toll-like receptor 3 trans-membrane domain

cd21340
Location:503 → 649

PPP1R42; protein phosphatase 1 regulatory subunit 42
XM_006509281.4 → XP_006509344.1 toll-like receptor 3 isoform X1

See identical proteins and their annotated locations for XP_006509344.1

UniProtKB/Swiss-Prot

Q91ZM4, Q99MB1

UniProtKB/TrEMBL

Q499F3

Conserved Domains (7) summary

smart00082
Location:646 → 698

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:756 → 901

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:70 → 543

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:589 → 610

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:277 → 300

LRR_RI; leucine-rich repeat [structural motif]

pfam17968
Location:699 → 731

Tlr3_TMD; Toll-like receptor 3 trans-membrane domain

cd21340
Location:503 → 649

PPP1R42; protein phosphatase 1 regulatory subunit 42
XM_006509283.4 → XP_006509346.1 toll-like receptor 3 isoform X1

See identical proteins and their annotated locations for XP_006509346.1

UniProtKB/Swiss-Prot

Q91ZM4, Q99MB1

UniProtKB/TrEMBL

Q499F3

Conserved Domains (7) summary

smart00082
Location:646 → 698

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:756 → 901

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:70 → 543

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:589 → 610

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:277 → 300

LRR_RI; leucine-rich repeat [structural motif]

pfam17968
Location:699 → 731

Tlr3_TMD; Toll-like receptor 3 trans-membrane domain

cd21340
Location:503 → 649

PPP1R42; protein phosphatase 1 regulatory subunit 42
XM_006509278.4 → XP_006509341.1 toll-like receptor 3 isoform X1

See identical proteins and their annotated locations for XP_006509341.1

UniProtKB/Swiss-Prot

Q91ZM4, Q99MB1

UniProtKB/TrEMBL

Q499F3

Conserved Domains (7) summary

smart00082
Location:646 → 698

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:756 → 901

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:70 → 543

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:589 → 610

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:277 → 300

LRR_RI; leucine-rich repeat [structural motif]

pfam17968
Location:699 → 731

Tlr3_TMD; Toll-like receptor 3 trans-membrane domain

cd21340
Location:503 → 649

PPP1R42; protein phosphatase 1 regulatory subunit 42