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    NLM1 NOD26-like major intrinsic protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827641, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NLM1
    Official Full Name
    NOD26-like major intrinsic protein 1
    Primary source
    TAIR:AT4G19030
    Locus tag
    AT4G19030
    See related
    Araport:AT4G19030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AT-NLM1; ATNLM1; F13C5.200; F13C5_200; NIP1;1; NOD26-LIKE INTRINSIC PROTEIN 1;1; NOD26-like major intrinsic protein 1; NOD26-LIKE MAJOR INTRINSIC PROTEIN 1
    Summary
    an aquaporin whose expression level is reduced by ABA, NaCl, dark, and dessication. is expressed at relatively low levels under normal conditions. Also functions in arsenite transport and tolerance.
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    Genomic context

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    See NLM1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Sequence:
    Chromosome: 4; NC_003075.7 (10421521..10423508, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Proteasome component (PCI) domain protein Neighboring gene AMP-dependent synthetase and ligase family protein Neighboring gene chromomethylase 2 Neighboring gene low-molecular-weight cysteine-rich 7 Neighboring gene low-molecular-weight cysteine-rich 15

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide Association Study Reveals that the Aquaporin NIP1;1 Contributes to Variation in Hydrogen Peroxide Sensitivity in Arabidopsis thaliana. Sadhukhan A, et al. Mol Plant, 2017 Aug 7. PMID 28712931
    2. Arabidopsis NIP1;1 transports antimonite and determines antimonite sensitivity. Kamiya T, et al. Plant Cell Physiol, 2009 Nov. PMID 19783540
    3. NIP1;1, an aquaporin homolog, determines the arsenite sensitivity of Arabidopsis thaliana. Kamiya T, et al. J Biol Chem, 2009 Jan 23. PMID 19029297
    4. The major intrinsic protein family of Arabidopsis has 23 members that form three distinct groups with functional aquaporins in each group. Weig A, et al. Plant Physiol, 1997 Aug. PMID 9276952, Free PMC Article
    5. Independently evolved virulence effectors converge onto hubs in a plant immune system network. Mukhtar MS, et al. Science, 2011 Jul 29. PMID 21798943, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Disruption of NIP1;1 confers antimonite tolerance.
      Title: Arabidopsis NIP1;1 transports antimonite and determines antimonite sensitivity.
    2. NIP1;1 is involved in arsenite uptake into roots
      Title: NIP1;1, an aquaporin homolog, determines the arsenite sensitivity of Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001341319.1
    NM_001341320.1
    NM_118021.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables arsenite transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables water channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables water channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within arsenite transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within hydrogen peroxide transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within hydrogen peroxide transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to arsenic-containing substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    NOD26-like major intrinsic protein 1
    NP_567572.1
    • NOD26-like major intrinsic protein 1 (NLM1); CONTAINS InterPro DOMAIN/s: Major intrinsic protein, conserved site (InterPro:IPR022357), Aquaporin (InterPro:IPR012269), Major intrinsic protein (InterPro:IPR000425); BEST Arabidopsis thaliana protein match is: NOD26-like intrinsic protein 1;2 (TAIR:AT4G18910.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      10421521..10423508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118021.4 → NP_567572.1  NOD26-like major intrinsic protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567572.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48595, O49416, Q8VZW1
      UniProtKB/TrEMBL
      A0A178V521, A0A221J3L5, A0A221J3M9, A0A384L612, A0A7G2F3T1
      Conserved Domains (1) summary
      PLN00184
      Location:1 → 296
      PLN00184; aquaporin NIP1; Provisional

    2. NM_001341319.1 → NP_001328744.1  NOD26-like major intrinsic protein 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B5K3

    3. NM_001341320.1 → NP_001328743.1  NOD26-like major intrinsic protein 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B5K6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VZW1.1

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