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    CRK13 cysteine-rich RLK (RECEPTOR-like protein kinase) 13 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828420, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CRK13
    Official Full Name
    cysteine-rich RLK (RECEPTOR-like protein kinase) 13
    Primary source
    TAIR:AT4G23210
    Locus tag
    AT4G23210
    See related
    Araport:AT4G23210
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cysteine-rich RLK (RECEPTOR-like protein kinase) 13; F21P8.100; F21P8_100; HIG1; HIGH INDOLIC GLUCOSINOLATE 1
    Summary
    Encodes a Cysteine-rich receptor-like kinase (CRK13). Overexpression of CRK13 leads to hypersensitive response cell death, and induces defense against pathogens by causing increased accumulation of salicylic acid.
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    Genomic context

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    See CRK13 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    7
    Sequence:
    Chromosome: 4; NC_003075.7 (12148673..12151638, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene cysteine-rich RLK (RECEPTOR-like protein kinase) 12 Neighboring gene miscRNA Neighboring gene cysteine-rich RECEPTOR-like kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of CRK13, an Arabidopsis cysteine-rich receptor-like kinase, results in enhanced resistance to Pseudomonas syringae. Acharya BR, et al. Plant J, 2007 May. PMID 17419849
    2. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    3. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upregulation of CRK13 leads to hypersensitive response-associated cell death, and induces defense against pathogens by causing increased accumulation of salicylic acid.
      Title: Overexpression of CRK13, an Arabidopsis cysteine-rich receptor-like kinase, results in enhanced resistance to Pseudomonas syringae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001084966.2
    NM_001341586.1
    NM_118450.4
    NM_179096.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type hypersensitive response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to molecule of bacterial origin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cysteine-rich RLK (RECEPTOR-like protein kinase) 13
    NP_001078435.1
    • cysteine-rich RLK (RECEPTOR-like protein kinase) 13 (CRK13); FUNCTIONS IN: kinase activity; INVOLVED IN: defense response to bacterium, response to molecule of bacterial origin, plant-type hypersensitive response; LOCATED IN: endomembrane system; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Protein of unknown function DUF26 (InterPro:IPR002902), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: cysteine-rich RLK (RECEPTOR-like protein kinase) 22 (TAIR:AT4G23300.1); Has 115691 Blast hits to 114357 proteins in 4390 species: Archae - 92; Bacteria - 13299; Metazoa - 42539; Fungi - 9809; Plants - 32940; Viruses - 418; Other Eukaryotes - 16594 (source: NCBI BLink).
    NP_194052.2
    • cysteine-rich RLK (RECEPTOR-like protein kinase) 13 (CRK13); FUNCTIONS IN: kinase activity; INVOLVED IN: defense response to bacterium, response to molecule of bacterial origin, plant-type hypersensitive response; LOCATED IN: endomembrane system; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Protein of unknown function DUF26 (InterPro:IPR002902), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: cysteine-rich RLK (RECEPTOR-like protein kinase) 22 (TAIR:AT4G23300.1); Has 114660 Blast hits to 113447 proteins in 4374 species: Archae - 92; Bacteria - 13215; Metazoa - 42360; Fungi - 9577; Plants - 32731; Viruses - 419; Other Eukaryotes - 16266 (source: NCBI BLink).
    NP_849427.1
    • cysteine-rich RLK (RECEPTOR-like protein kinase) 13 (CRK13); FUNCTIONS IN: kinase activity; INVOLVED IN: defense response to bacterium, response to molecule of bacterial origin, plant-type hypersensitive response; LOCATED IN: endomembrane system; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Protein of unknown function DUF26 (InterPro:IPR002902), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: cysteine-rich RLK (RECEPTOR-like protein kinase) 22 (TAIR:AT4G23300.1); Has 81996 Blast hits to 81416 proteins in 3653 species: Archae - 64; Bacteria - 8231; Metazoa - 29233; Fungi - 6119; Plants - 28323; Viruses - 237; Other Eukaryotes - 9789 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12148673..12151638 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001341587.1 → NP_001329247.1  cysteine-rich RLK (RECEPTOR-like protein kinase) 13 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B741

    2. NM_001084966.2 → NP_001078435.1  cysteine-rich RLK (RECEPTOR-like protein kinase) 13 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078435.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65473, Q0PW40, Q8H0Y5, Q8H1R8
      UniProtKB/TrEMBL
      A0A5S9XVF7, A0A654FS29
      Conserved Domains (2) summary
      cd14066
      Location:364 → 628
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
      pfam01657
      Location:26 → 124
      Stress-antifung; Salt stress response/antifungal

    3. NM_118450.4 → NP_194052.2  cysteine-rich RLK (RECEPTOR-like protein kinase) 13 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194052.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FS29
      Conserved Domains (2) summary
      pfam01657
      Location:26 → 124
      Stress-antifung; Salt stress response/antifungal
      cl21453
      Location:364 → 561
      PKc_like; Protein Kinases, catalytic domain

    4. NM_179096.3 → NP_849427.1  cysteine-rich RLK (RECEPTOR-like protein kinase) 13 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849427.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0PW40
      Conserved Domains (2) summary
      pfam01657
      Location:26 → 124
      Stress-antifung; Salt stress response/antifungal
      cl21453
      Location:364 → 524
      PKc_like; Protein Kinases, catalytic domain

    5. NM_001341586.1 → NP_001329248.1  cysteine-rich RLK (RECEPTOR-like protein kinase) 13 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0PW40
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0PW40.1

    Gene LinkOut

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