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    Patched family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829992, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Patched family protein
    Primary source
    TAIR:AT4G38350
    Locus tag
    AT4G38350
    See related
    Araport:AT4G38350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F22I13.120; F22I13_120
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    39
    Sequence:
    Chromosome: 4; NC_003075.7 (17958096..17966962, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene hemolysin-III integral membrane-like protein Neighboring gene Plant regulator RWP-RK family protein Neighboring gene organic solute transporter ostalpha protein (DUF300) Neighboring gene Phosphoglycerate mutase family protein Neighboring gene MATE efflux family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Misexpression of the Niemann-Pick disease type C1 (NPC1)-like protein in Arabidopsis causes sphingolipid accumulation and reproductive defects. Feldman MJ, et al. Planta, 2015 Oct. PMID 26007685
    2. Large-scale characterization of integral proteins from Arabidopsis vacuolar membrane by two-dimensional liquid chromatography. Szponarski W, et al. Proteomics, 2004 Feb. PMID 14760709
    3. The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Carter C, et al. Plant Cell, 2004 Dec. PMID 15539469, Free PMC Article
    4. A proteomics dissection of Arabidopsis thaliana vacuoles isolated from cell culture. Jaquinod M, et al. Mol Cell Proteomics, 2007 Mar. PMID 17151019, Free PMC Article
    5. Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics. Nikolovski N, et al. Plant Physiol, 2012 Oct. PMID 22923678, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001204024.1
    NM_119997.7

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within pollen tube development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of sphingolipid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    Patched family protein
    NP_001190953.1
    • Patched family protein; FUNCTIONS IN: hedgehog receptor activity; LOCATED IN: membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Niemann-Pick C type protein (InterPro:IPR004765), Patched (InterPro:IPR003392), Sterol-sensing 5TM box (InterPro:IPR000731); BEST Arabidopsis thaliana protein match is: Patched family protein (TAIR:AT1G42470.1).
    NP_195548.6
    • Patched family protein; FUNCTIONS IN: hedgehog receptor activity; LOCATED IN: plasma membrane, vacuole, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Niemann-Pick C type protein (InterPro:IPR004765), Patched (InterPro:IPR003392), Sterol-sensing 5TM box (InterPro:IPR000731); BEST Arabidopsis thaliana protein match is: Patched family protein (TAIR:AT1G42470.1); Has 3325 Blast hits to 2735 proteins in 472 species: Archae - 80; Bacteria - 454; Metazoa - 1756; Fungi - 181; Plants - 170; Viruses - 0; Other Eukaryotes - 684 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      17958096..17966962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119997.7 → NP_195548.6  Patched family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195548.6

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F457, F4JTN0
      Conserved Domains (4) summary
      TIGR00917
      Location:38 → 1251
      2A060601; Niemann-Pick C type protein family
      pfam12349
      Location:664 → 790
      Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
      pfam16414
      Location:37 → 265
      NPC1_N; Niemann-Pick C1 N terminus
      cl21543
      Location:1104 → 1252
      MMPL; MMPL family

    2. NM_001204024.1 → NP_001190953.1  Patched family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190953.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F457, F4JTN1
      Conserved Domains (4) summary
      TIGR00917
      Location:38 → 1275
      2A060601; Niemann-Pick C type protein family
      pfam12349
      Location:688 → 814
      Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
      pfam16414
      Location:37 → 265
      NPC1_N; Niemann-Pick C1 N terminus
      cl21543
      Location:1128 → 1276
      MMPL; MMPL family
    Nucleotide Protein
    Heading Accession and Version

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