UXS5 UDP-XYL synthase 5 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: UXS5
Official Full Name: UDP-XYL synthase 5
Primary source: TAIR:AT3G46440
Locus tag: AT3G46440
See related: Araport:AT3G46440
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: UDP-XYL synthase 5
Summary: encodes a protein similar to UDP-glucuronic acid decarboxylase. UDP-glucuronic acid decarboxylase produces UDP-xylose, which is a substrate for many cell wall carbohydrates including hemicellulose and pectin. UDP-xylose is also known to feedback regulate several cell wall biosynthetic enzymes.
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Genomic context

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See UXS5 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 11

Sequence:: Chromosome: 3; NC_003074.8 (17089013..17092065, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results demonstrate that the cytosol-localized UDP-xylose synthases UXS3, UXS5 and UXS6 play a predominant role in the supply of UDP-xylose for the biosynthesis of xylan and xyloglucan.
Title: Cytosol-Localized UDP-Xylose Synthases Provide the Major Source of UDP-Xylose for the Biosynthesis of Xylan and Xyloglucan.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001035743.2

Supported by ESTs:

NM_114511.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables UDP-glucuronate decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables UDP-glucuronate decarboxylase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within D-xylose metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in UDP-D-xylose biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within xylan biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: UDP-XYL synthase 5

NP_001030820.1

UDP-XYL synthase 5 (UXS5); FUNCTIONS IN: UDP-glucuronate decarboxylase activity, catalytic activity; INVOLVED IN: nucleotide-sugar metabolic process, D-xylose metabolic process; LOCATED IN: chloroplast; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: UDP-glucuronic acid decarboxylase 3 (TAIR:AT5G59290.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_190228.1

UDP-XYL synthase 5 (UXS5); FUNCTIONS IN: UDP-glucuronate decarboxylase activity, catalytic activity; INVOLVED IN: nucleotide-sugar metabolic process, D-xylose metabolic process; LOCATED IN: chloroplast; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: UDP-glucuronic acid decarboxylase 3 (TAIR:AT5G59290.2); Has 43250 Blast hits to 43194 proteins in 3018 species: Archae - 841; Bacteria - 25483; Metazoa - 667; Fungi - 365; Plants - 1392; Viruses - 87; Other Eukaryotes - 14415 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

17089013..17092065 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_114511.4 → NP_190228.1 UDP-XYL synthase 5 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_190228.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SN95

UniProtKB/TrEMBL

A0A178VDJ4, A0A5S9XJ45, A0A7G2EBV3

Conserved Domains (1) summary

cd05230
Location:29 → 333

UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
NM_001035743.2 → NP_001030820.1 UDP-XYL synthase 5 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001030820.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SN95

UniProtKB/TrEMBL

A0A178VDJ4, A0A5S9XJ45, A0A7G2EBV3

Conserved Domains (1) summary

cd05230
Location:29 → 333

UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs