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    FC1 serine/threonine-protein kinase AFC1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824525, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FC1
    Official Full Name
    serine/threonine-protein kinase AFC1
    Primary source
    TAIR:AT3G53570
    Locus tag
    AT3G53570
    See related
    Araport:AT3G53570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AFC1; AME2; CLK/STY (LAMMER-TYPE) PROTEIN KINASE; FUS3-complementing gene 1
    Summary
    a member of a CDC2-related kinase subfamily, the LAMMER kinases. activates STE12-dependent functions in yeast.
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    Genomic context

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    See FC1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Sequence:
    Chromosome: 3; NC_003074.8 (19861177..19864588, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Chloroplast-targeted copper chaperone protein Neighboring gene afadin Neighboring gene FBD-like domain family protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene diaminopimelate epimerase family protein Neighboring gene LRR receptor-like Serine/Threonine-kinase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AFC1, a LAMMER kinase from Arabidopsis thaliana, activates STE12-dependent processes in yeast. Bender J, et al. Proc Natl Acad Sci U S A, 1994 Dec 6. PMID 7991592, Free PMC Article
    2. Proteomic profiling of tandem affinity purified 14-3-3 protein complexes in Arabidopsis thaliana. Chang IF, et al. Proteomics, 2009 Jun. PMID 19452453, Free PMC Article
    3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    NM_001035776.1
    NM_001339622.1
    NM_115217.3
    NM_180364.4
    NM_202696.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase AFC1
    NP_001030853.1
    • FUS3-complementing gene 1 (FC1); CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: FUS3-complementing gene 2 (TAIR:AT4G24740.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_190925.1
    • FUS3-complementing gene 1 (FC1); CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: FUS3-complementing gene 2 (TAIR:AT4G24740.1); Has 85182 Blast hits to 83832 proteins in 2481 species: Archae - 54; Bacteria - 8197; Metazoa - 34642; Fungi - 12053; Plants - 13602; Viruses - 315; Other Eukaryotes - 16319 (source: NCBI BLink).
    NP_850695.2
    • FUS3-complementing gene 1 (FC1); CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: FUS3-complementing gene 2 (TAIR:AT4G24740.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_974425.1
    • FUS3-complementing gene 1 (FC1); CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: FUS3-complementing gene 2 (TAIR:AT4G24740.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      19861177..19864588 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115217.3 → NP_190925.1  serine/threonine-protein kinase AFC1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190925.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P51566, Q39184
      UniProtKB/TrEMBL
      A0A5S9XKS7, A0A654FHV3, B9DH08
      Conserved Domains (1) summary
      cd14134
      Location:102 → 443
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases

    2. NM_180364.4 → NP_850695.2  serine/threonine-protein kinase AFC1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850695.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P51566, Q39184
      UniProtKB/TrEMBL
      A0A5S9XKS7, A0A654FHV3, B9DH08
      Conserved Domains (1) summary
      cd14134
      Location:102 → 443
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases

    3. NM_202696.3 → NP_974425.1  serine/threonine-protein kinase AFC1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974425.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XKS7, F4JAH3
      Conserved Domains (2) summary
      smart00220
      Location:101 → 429
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14134
      Location:88 → 429
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases

    4. NM_001035776.1 → NP_001030853.1  serine/threonine-protein kinase AFC1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030853.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P51566, Q39184
      UniProtKB/TrEMBL
      A0A5S9XKS7, A0A654FHV3, B9DH08
      Conserved Domains (1) summary
      cd14134
      Location:102 → 443
      PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases

    5. NM_001339622.1 → NP_001327608.1  serine/threonine-protein kinase AFC1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XKS7, F4JAH3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51566.2

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