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    UPP uracil phosphoribosyltransferase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824557, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UPP
    Official Full Name
    uracil phosphoribosyltransferase
    Primary source
    TAIR:AT3G53900
    Locus tag
    AT3G53900
    See related
    Araport:AT3G53900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    PYRIMIDINE R; PYRR; uracil phosphoribosyltransferase
    Summary
    Encodes UPP, a plastidial uracil phosphoribosyltransferase (UPRT) involved in uracil salvage. Loss-of-function mutation causes dramatic growth retardation, a pale-green to albino phenotype, abnormal root morphology and chloroplastic disorders.
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    Genomic context

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    See UPP in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    12
    Sequence:
    Chromosome: 3; NC_003074.8 (19956590..19959075, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene NAD(P)-linked oxidoreductase superfamily protein Neighboring gene Ribosomal protein S21e Neighboring gene malate dehydrogenase-like protein Neighboring gene RNApolymerase sigma-subunit C Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unravelling the potential of a new uracil phosphoribosyltransferase (UPRT) from Arabidopsis thaliana in sensitizing HeLa cells towards 5-fluorouracil. Narayanan S, et al. Int J Biol Macromol, 2016 Oct. PMID 27180296
    2. Uracil salvage is necessary for early Arabidopsis development. Mainguet SE, et al. Plant J, 2009 Oct. PMID 19563437
    3. Effects of phosphate limitation on expression of genes involved in pyrimidine synthesis and salvaging in Arabidopsis. Hewitt MM, et al. Plant Physiol Biochem, 2005 Feb. PMID 15820655
    4. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article
    5. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Unravelling the potential of a new uracil phosphoribosyltransferase (UPRT) from Arabidopsis thaliana in sensitizing HeLa cells towards 5-fluorouracil.
      Title: Unravelling the potential of a new uracil phosphoribosyltransferase (UPRT) from Arabidopsis thaliana in sensitizing HeLa cells towards 5-fluorouracil.
    2. the mono-domain UPP gene encodes a functional uracil phosphoribosyltransferase. Loss of UPRT activity strongly affects early Arabidopsis development.
      Title: Uracil salvage is necessary for early Arabidopsis development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_115250.3
    NM_180368.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables uracil phosphoribosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in UMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to phosphate starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within developmental process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in uracil salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in plastid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uracil phosphoribosyltransferase
    NP_190958.1
    • uracil phosphoribosyltransferase (UPP); FUNCTIONS IN: uracil phosphoribosyltransferase activity; INVOLVED IN: cellular response to phosphate starvation, developmental process, nucleoside metabolic process; LOCATED IN: chloroplast, plastid; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Phosphoribosyltransferase (InterPro:IPR000836), Uracil phosphoribosyl transferase (InterPro:IPR005765); BEST Arabidopsis thaliana protein match is: uridine kinase-like 5 (TAIR:AT3G27440.1); Has 6282 Blast hits to 6282 proteins in 2386 species: Archae - 194; Bacteria - 4411; Metazoa - 238; Fungi - 342; Plants - 200; Viruses - 0; Other Eukaryotes - 897 (source: NCBI BLink).
    NP_850699.1
    • uracil phosphoribosyltransferase (UPP); FUNCTIONS IN: uracil phosphoribosyltransferase activity; INVOLVED IN: cellular response to phosphate starvation, developmental process, nucleoside metabolic process; LOCATED IN: chloroplast, plastid; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Phosphoribosyltransferase (InterPro:IPR000836), Uracil phosphoribosyl transferase (InterPro:IPR005765); BEST Arabidopsis thaliana protein match is: uridine kinase-like 2 (TAIR:AT3G27190.1); Has 6281 Blast hits to 6281 proteins in 2387 species: Archae - 194; Bacteria - 4412; Metazoa - 236; Fungi - 342; Plants - 200; Viruses - 0; Other Eukaryotes - 897 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      19956590..19959075 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115250.3 → NP_190958.1  uracil phosphoribosyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190958.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EAK0, Q8LFM4, Q9M336
      UniProtKB/TrEMBL
      A0A178VJX7, A0A5S9XMA4
      Conserved Domains (1) summary
      PLN02541
      Location:48 → 291
      PLN02541; uracil phosphoribosyltransferase

    2. NM_180368.2 → NP_850699.1  uracil phosphoribosyltransferase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850699.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M336
      Conserved Domains (1) summary
      PLN02541
      Location:1 → 226
      PLN02541; uracil phosphoribosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M336.1

    Gene LinkOut

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